c. 300 B.C. - Alcmaeon of Croton distinguished veins from arteries and discovered the optic nerve.
c. 200 B.C. - Sushruta - wrote Sushruta Samhita describing over 120 surgical instruments, 300 surgical procedures and classified human surgery in 8 categories. Performed cosmetic surgery.
c. 400 B.C. - Xenophanes examined fossils and speculated on the evolution of life.
c.700 B.C. - Aristotle attempted a comprehensive classification of animals. His written works include Historion Animalium, a general biology of animals, De Partibus Animalium, a comparative anatomy and physiology of animals, and De Generatione Animalium, on developmental biology.
c. 600 BC - Theophrastos (or Theophrastus) begins the systematic study of botany.
c. 900 B.C. - Herophilos dissected the human body.
c. 100 B.C. - Diocles wrote the last known anatomy book and was the first to use the term anatomy.
c. 50-70 - Historia Naturalis by Pliny the Elder (Gaius Plinius Secundus) was published in 37 volumes.
130-200 - Claudius Galen wrote numerous treatises on human anatomy.
c. 1010 - Avicenna (Ibn Sina or Abu Ali al Hussein ibn Abdallah) published his Canon of Medicine (Kitab al-Qanun fi al-tibb).
1543 - Andreas Vesalius publishes the anatomy treatise De humani corporis fabrica.
?? - Jan Baptist van Helmont performs his famous tree plant experiment in which he shows that the substance of a plant derives from water and air, the first description of photosynthesis.
1628 - William Harvey publishes An Anatomical Exercise on the Motion of the Heart and Blood in Animals
1651 - William Harvey concludes that all animals, including mammals, develop from eggs, and spontaneous generation of any animal from mud or excrement was an impossibility.
1658 - Jan Swammerdam observes red blood cells under a microscope.
1663 - Robert Hooke sees cells in cork using a microscope.
1668 - Francesco Redi disproves spontaneous generation by showing that fly maggots only appear on pieces of meat in jars if the jars are open to the air. Jars covered with cheesecloth contained no flies.
1672 - Marcello Malpighi publishes the first description of chick development, including the formation of muscle somites, circulation, and nervous system.
1676 - Anton van Leeuwenhoek observes protozoa and calls them animalcules.
1677 - Anton van Leeuwenhoek observes spermatozoa.
1683 - Anton van Leeuwenhoek observes bacteria. Leeuwenhoek's discoveries renew the question of spontaneous generation in microorganisms.
1767 - Kaspar Friedrich Wolff argues that the tissues of a developing chick form from nothing and are not simply elaborations of already-present structures in the egg.
1768 - Lazzaro Spallanzani again disproves spontaneous generation by showing that no organisms grow in a rich broth if it is first heated (to kill any organisms) and allowed to cool in a stoppered flask. He also shows that fertilization in mammals requires an egg and semen.
1798 - Thomas Malthus discusses human population growth and food production in An Essay on the Principle of Population.
1801 - Jean-Baptiste Lamarck begins the detailed study of invertebrate taxonomy.
1802 - The term biology in its modern sense is propounded independently by Gottfried Reinhold Treviranus (Biologie oder Philosophie der lebenden Natur) and Lamarck (Hydrogéologie). The word had been coined in 1800 by Karl Friedrich Burdach.
1809 - Lamarck proposes a modern theory of evolution based on the inheritance of acquired characteristics.
1817 - Pierre-Joseph Pelletier and Joseph-Bienaime Caventou isolate chlorophyll.
1820 - Christian Friedrich Nasse formulates Nasse's law: hemophilia occurs only in males and is passed on by unaffected females.
1824 - J. L Prevost and J. B. Dumas showed that the sperm in semen were not parasites, as previously thought, but, instead, the agents of fertilization.
1826 - Karl von Baer shows that the eggs of mammals are in the ovaries, ending a 200-year search for the mammalian egg.
1858 - Charles R. Darwin and Alfred Wallace independently propose a theory of biological evolution ("descent through modification") by means of natural selection. Only in later editions of his works did Darwin used the term "evolution."
1858 - Rudolf Virchow proposes that cells can only arise from pre-existing cells; "Omnis cellula e celulla," all cell from cells. The Cell Theory states that all organisms are composed of cells (Schleiden and Schwann), and cells can only come from other cells (Virchow).
1864 - Louis Pasteur disproves the spontaneous generation of cellular life.
1865 - Gregor Mendel demonstrates in pea plants that inheritance follows definite rules. The Principle of Segregation states that each organism has two genes per trait, which segregate when the organism makes eggs or sperm. The Principle of Independent Assortment states that each gene in a pair is distributed independently during the formation of eggs or sperm. Mendel's trailblazing foundation for the science of genetics went unnoticed, to his lasting disappointment.
1874 - Jacobus van 't Hoff and Joseph-Achille Le Bel advance a three-dimensional stereochemical representation of organic molecules and propose a tetrahedral carbon atom.
1876 - Oskar Hertwig and Hermann Fol independently describe (in sea urchin eggs) the entry of sperm into the egg and the subsequent fusion of the egg and sperm nuclei to form a single new nucleus.
1884 - Emil Fischer begins his detailed analysis of the compositions and structures of sugars.
1892 - Hans Driesch separates the individual cells of a 2-cell sea urchin embryo and shows that each cell develops into a complete individual, thus disproving the theory of preformation and showing that each cell is "totipotent," containing all the hereditary information necessary to form an individual.
1898 - Martinus Beijerinck uses filtering experiments to show that tobacco mosaic disease is caused by something smaller than a bacterium, which he names a virus.
1900 - Two biologists independently rediscover Mendel's paper on heredity.
1902 - Walter Sutton and Theodor Boveri, independently propose that the chromosomes carry the hereditary information.
1905 - William Bateson coins the term "genetics" to describe the study of biological inheritance.
1906 - Mikhail Tsvet discovers the chromatography technique for organic compound separation.
1907 - Ivan Pavlov demonstrates conditioned responses with salivating dogs.
1907 - Emil Fischer artificially synthesizes peptideamino acid chains and thereby shows that amino acids in proteins are connected by amino group-acid group bonds.
1909 - Wilhelm Johannsen coined the word "gene."
1911 - Thomas Hunt Morgan proposes that genes are arranged in a line on the chromosomes.
1926 - James Sumner shows that the urease enzyme is a protein.
1928 - Otto Diels and Kurt Alder discover the Diels-Alder cycloaddition reaction for forming ring molecules.
1937 - In Genetics and the Origin of Species, Theodosius Dobzhansky applies the chromosome theory and population genetics to natural populations in the first mature work of neo-Darwinism, also called the modern synthesis, a term coined by Julian Huxley.
1938 - A living coelacanth is found off the coast of southern Africa.
1940 - Donald Griffin and Robert Galambos announce their discovery of sonar echolocation by bats.
1942 - Max Delbruck and Salvador Luria demonstrate that bacterial resistance to virus infection is caused by random mutation and not adaptive change.
1952 - American developmental biologists Robert Briggs and Thomas King clone the first vertebrate by transplanting nuclei from leopard frogs embryos into enucleated eggs. More differentiated cells were the less able they are to direct development in the enucleated egg.
1952 - Alfred Hershey and Martha Chase show that DNA is the genetic material in bacteriophage viruses.
1952 - Fred Sanger, Hans Tuppy, and Ted Thompson complete their chromatographic analysis of the insulin amino acid sequence.
1952 - Rosalind Franklin concludes that DNA is a double helix with a diameter of 2 nm and the sugar-phosphate backbones on the outside of the helix, based on x ray diffraction studies. She suspects the two sugar-phosphate backbones have a peculiar relationship to each other.
1953 - After examining Franklin's unpublished data, James D. Watson and Francis Crick publish a double-helix structure for DNA, with one sugar-phosphate backbone running in the opposite direction to the other. They further suggest a mechanism by which the molecule can replicate itself and serve to transmit genetic information. Their paper, combined with the Hershey-Chase experiment and Chargaff's data on nucleotides, finally persuades biologists that DNA is the genetic material, not protein.
1961 - German plant physiologist H. J. Matthaei cracks the first codon of the genetic code (the codon for the amino acid phenylalanine) using Grunberg-Manago's enzyme system for making polynucleotides.
1972 - Stephen Jay Gould and Niles Eldredge propose an idea they call "punctuated equilibrium," which states that the fossil record is an accurate depiction of the pace of evolution, with long periods of "stasis" (little change) punctuated by brief periods of rapid change and species formation (within a lineage).
1972 - SJ Singer and GL Nicholson develop the fluid mosaic model, which deals with the make-up of the membrane of all cells.
1974 - Manfred Eigen and Manfred Sumper show that mixtures of nucleotide monomers and RNA replicase will give rise to RNA molecules which replicate, mutate, and evolve.
1974 - Leslie Orgel shows that RNA can replicate without RNA-replicase and that zinc aids this replication.
1977 - John Corliss, Jack Dymond, Louis Gordon, John Edmond, Richard von Herzen, Robert Ballard, Kenneth Green, David Williams, Arnold Bainbridge, Kathy Crane, and Tjeerd van Andel discover chemosynthetically based animal communities located around submarine hydrothermal vents on the Galapagos Rift.
^ The date at which the Sushruta Samhita was compiled is uncertain.
A Tribute to Hinduism says Sushruta lived in the 5th century B.C., and so the date 500 B.C. may be too early.
History of biology
Fields and disciplines
Natural history • History of agriculture • History of medicine • History of anatomy • History of zoology (before Darwin)• History of plant systematics • History of geology • History of paleontology • History of evolutionary thought • History of zoology (after Darwin) • History of ecology • History of model organisms • History of phycology • History of genetics • History of biochemistry • History of agricultural science • History of molecular biology • History of molecular evolution • History of immunology • History of biotechnology
Rothamsted Experimental Station • Pasteur Institute • Max Planck Society • Cold Spring Harbor Laboratory • Stazione Zoologica • Marine Biological Laboratory • Rockefeller University • Woods Hole Oceanographic Institute • Laboratory of Molecular Biology
Griffith's experiment • Miller-Urey experiment • Luria-Delbrück experiment • Hershey-Chase experiment • Meselson-Stahl experiment • Crick, Brenner et al. experiment • Nirenberg and Matthaei experiment • Nirenberg and Leder experiment
On Generation and Corruption • Historia Plantarum • De humani corporis fabrica • De motu cordis • Micrographia • Systema Naturae • Philosophie Zoologique • Principles of Geology • Vestiges of Creation • The Origin of Species • "Experiments on Plant Hybridization" • The Descent of Man • "The Correlation Between Relatives on the Supposition of Mendelian Inheritance" • What is Life? • Genetics and the Origin of Species • "Molecular structure of Nucleic Acids"
History of science • History of medicine • Philosophy of biology • Timeline of biology and organic chemistry • Natural philosophy • Natural theology • Humboldtian science • Relationship between religion and science • Eugenics • Human Genome Project • Darwin Day • History of creationism • History of the creation-evolution controversy