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Systematic (IUPAC) name
2-[3-[bis(1-methylethyl)amino]- 1-phenyl-propyl]-4-methyl-phenol
CAS number 124937-51-5
ATC code G04BD07
PubChem 60774
DrugBank APRD00146
Chemical data
Formula C22H31NO 
Mol. mass 325.488 g/mol
Pharmacokinetic data
Bioavailability 77%
Protein binding Approximately 96.3%.
Metabolism  ?
Half life 1.9-3.7 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.


Legal status
Routes  ?

Tolterodine is an antimuscarinic drug that is used to treat urinary incontinence. It is sold under the trade name Detrol.


Tolterodine acts on M2 and M3 subtypes of muscarinic receptors whereas most antimuscarinic treatments for overactive bladder only act on M3 receptors making them more selective.

Tolterodine, although it acts on two types of receptors, has fewer side effects than other antimuscarinics eg. oxybutynin (which is selective for M3 only) as tolterodine targets the bladder more than other areas of the body. This means that less drug needs to be given daily (due to efficient targeting of the bladder) and so there are fewer side effects.

Side effects

Known Side Effects:

  • Hyposalivation (Dry mouth)
  • Decreased gastric motility (Upset stomach)
  • Headache
  • Constipation
  • Dry eyes
  • Sleepiness

Reports of Patients’ Experiences Since Detrol Became Available:

The following reactions have been reported in patients who have taken Detrol since it has become available:

  • Allergic reactions including swelling
  • Rapid heartbeat or abnormal heartbeat
  • Accumulation of fluid in the arms and legs
  • Hallucinations

Contraindications Not to be used in patients with Myasthenia Gravis and Angle Closure Glaucoma

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Tolterodine". A list of authors is available in Wikipedia.
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