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Systematic (IUPAC) name
7-[3-hydroxy-2-(3-hydroxyoct-1-enyl)- 5-oxo-cyclopentyl] heptanoic acid
CAS number 745-65-3
ATC code C01EA01 G04BE01
PubChem 149351
DrugBank APRD00785
Chemical data
Formula C20H34O5 
Mol. mass 354.481 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.


Legal status
Routes  ?

Alprostadil is the pharmaceutical name for prostaglandin E1. It is used as a drug in the treatment of erectile dysfunction and has vasodilatory properties.[1]

Sexual dysfunction

Aprostidil is sold in the United States under the brand name Muse.[2] It is also sold as Caverject and Edex.

Muse delivers alprostadil as a penile suppository, inserted into the urethra, at least ten minutes before the erection will be needed. Caverject and Edex are similarly fast-acting, but are actually injected directly into the corpus cavernosum of the penis.

This drug is reputed to work for erectile dysfunction for 30 to 60 minutes.

This drug, following on the coattails of Viagra, has failed to achieve comparable above-ground market share in the United States, perhaps in part because of the invasive means of delivery.

NexMed is developing transdermal forumulations—Alprox-TD(R) for men with erectile dysfunction and Femprox(R) for female sexual arousal disorder. Alprox-TD(R) has been selling in China and in Hong Kong since October 2001 and April 2002, respectively. Two Phase III studies have been completed for this product, and the Company is seeking regulatory approval in the U.S., Canada and Europe. [3]

Other uses

Aprostadil is also used in maintaining a patent ductus arteriosus in the fetus. This is primarily useful when there is threat of premature closure of the ductus arteriosus.[1]


  1. ^ a b a_26/12123006 at Dorland's Medical Dictionary
  2. ^ Muse.
  3. ^ Fain Hughes (2007-10-29). NEXM: Dutton Sees Strong Speculative Buy and 12-Month Price Double. Retrieved on 2007-11-01.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Alprostadil". A list of authors is available in Wikipedia.
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