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In chemistry, topicity is the stereochemical relationship of substituents relative to the structure to which they are attached. Depending on the relationship, such groups can be homotopic, enantiotopic, or diastereotopic.
Additional recommended knowledge
Homotopic groups in a chemical compound are equivalent groups. Two groups A and B are homotopic if the molecule remains the same (including stereochemically) when the groups are interchanged with the remaining parts of the molecule fixed. Homotopic atoms have the same chemical shift in an NMR spectrum.
For example, the two hydrogen atoms attached to the second carbon in butane are enantiotopic. Replacement of one hydrogen atom (colored blue) with a bromine atom will produce (R)-2-bromobutane. Replacement of the other hydrogen atom (colored red) with a bromine atom will produce the enantiomer (S)-2-bromobutane.
For example, the two hydrogen atoms attached to the third carbon in (S)-2-bromobutane are diastereotopic. Replacement of one hydrogen atom (colored blue) with a bromine atom will produce (2S,3R)-2,3-dibromobutane. Replacement of the other hydrogen atom (colored red) with a bromine atom will produce the diastereomer (2S,3S)-2,3-dibromobutane.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Topicity". A list of authors is available in Wikipedia.|