Glycosylation

In the world of chemistry, good things can happen if you just add sugar. A wide range of drugs and biochemical probes -- everything from antibiotics to Alzheimer's disease biomarkers -- rely on natural or synthetic compounds that aid a reaction by adding carbohydrates. It's a process called glycosyl more

Agilent Technologies Inc. and Proteome Systems announced they have signed a marketing agreement to collaborate on an integrated solution for the analysis of glycoproteins, molecules that are important in the study of many diseases, including cancer, influenza and arthritis. Under the agreement, Prot more

The Dow Chemical Company and Plant Research International B.V. of Wageningen, The Netherlands, have agreed to join forces to speed development of therapeutic proteins with mammalian-like glycan structures in transgenic plants. Through their collaboration, the companies will work to expand the ut more

As demonstrated here, there are a broad range of HPLC applications used in development, production, validation and release of protein therapeutics for human use. Some of the applications mentioned above are mandatory when submitting a new biopharmace more

Molecules, Vol. 23, Pages 1547: Anti-Hepatitis C Virus Activity of Uridine Derivatives of 2-Deoxy Sugars Molecules doi: 10.3390/molecules23071547 Authors: Ewelina Krol Ilona Wandzik Gabriela Pastuch-Gawolek Boguslaw Szewczyk Hepatitis C virus (HCV), the etiological agent of the more

Chlamydia trachomatis ( Ct ) is the most common bacterium responsible for sexually transmitted infections. It constitutes a major public health burden, with the greatest clinical impact occurring in women of reproductive age. A vast proportion of Ct infections are underestimated because they are asy more

IJMS, Vol. 19, Pages 1837: N-Glycosylation Regulates Pannexin 2 Localization but Is Not Required for Interacting with Pannexin 1 International Journal of Molecular Sciences doi: 10.3390/ijms19071837 Authors: Rafael E. Sanchez-Pupo Danielle Johnston Silvia Penuela Pannexins (Panx1, more

Oliver Reimann received his master‘s degree in chemistry from Freie Universität Berlin. Since 2011, he has been working towards his doctorate as a member of the research group led by Professor Christian Hackenberger at the Leibniz Institute of Molecular Pharma­cology in Berlin and Freie Universität more