The Pan® Chromosome 21 Array consists of 498 specific gene sequences
and contains all genes known for chromosome 21, as well as additional
gene sequences whose location is supposed to be on that chromosome.
A cooperation with the Max Planck Institute for Molecular Genetics in Berlin
around this new DNA chip confirmed the superiority of MWG-Biotech’s
oligonucleotide DNA chip design applied in the Pan® Array Series. The
high degree of adaptability of MWG-Biotech’s oligonucleotide spotting
process allows for a totally flexible chip design that can be customized to
meet all customer requirements within a very short time. Additionally, as
demonstrated with the Pan® Chromosome 21 Array, chromosome sub sets
can be adequately developed.
„With the Pan® Chromosome 21 Array MWG-Biotech has successfully
established the Pan® Array principle for human applications. For this year
we are planning the introduction of additional DNA chips on the human
genome, especially a Pan® Array for cancer research and a Pan® Array
with the complete human genome of 30.000 genes,“ says Michael
Weichselgartner, CEO of MWG-Biotech.
The Pan® Chromosome 21 Array will be used for the investigation of
chromosome 21 related diseases. The best known application in that field
is the disease complex associated with Down Syndrome (DS), also called
trisomy 21 or mongolism. DS currently affects one out of 700 live births in
the population. DS research work centers especially on the complex of
circulatory diseases as well as on a special form of leukemia often
occurring in the context of DS. The Pan® Chromosome 21 Array is used to
study gene expression profiles of DS, which are compared against the
profiles of healthy people or patients with similar diseases but without DS.
With the development of the Pan® Chromosome 21 Array MWG-Biotech
hopes to contribute to a better understanding of disease genes located on