Lauren Pahnke, Field Applications Specialist, Gilson

Cost-efficient purification of natural compounds

Slica-free alternative to traditional HPLC columns for extraction, also from crude extracts

Chromatographic purification of natural compounds presents many challenges to scientists because of the complex nature of the starting matrices that are used in the process.
These starting materials can damage traditional columns and cartridges, decreasing the length of their usage and increasing costs; that is, if the particular system can even accommodate the starting material.
Centrifugal partition chromatography (CPC), which uses both liquid stationary and mobile phases, can handle heavily contaminated, complex starting materials, such as direct extracts from many biological sources, and has been shown useful for the isolation of piperine from Pipernigrum, gingerol from ginger and hundreds of other natural compounds from plants.
Additionally, by relying on a liquid stationary phase, CPC columns do not need to be replaced like traditional columns and cartridges used by preparative HPLC and flash chromatography methods.

This article will discuss the basic principles behind CPC and explore the use and benefits of CPC in the purification of cannabinoids from crude cannabis oil.

Facts, background information, dossiers
  • chromatographic pur…
  • piperine
  • natural compound pu…
More about Gilson
  • News

    Gilson announces the acquisition of Armen

    Gilson is pleased to announce the acquisition of Armen SAS. "The addition of the Armen Instruments product line allows Gilson to strengthen its purification solutions for every sample type, from manual to automated systems, addressing lab, pilot, and process scale solutions." said Atika El ... more

    Gilson Launches www.pipetman.eu, A New Online Store for the European Market

    Gilson S.A.S proudly announces the launch of www.pipetman.eu, a new online web shop that caters specifically to the European scientific market. Unveiled on August 1, 2010, www.pipetman.eu provides a multi-lingual platform that is offered in French, German and English. Orders for Gilson prod ... more

    Gilson announces new partners in the UK and Eire

    GILSON S.A.S. announced the appointment of new UK distributors in addition to establishing a new UK accredited service facility for UK customers. With effect from 1st January 2010, Scientific Laboratory Supplies (SLS) is now the official distributor for these brands. Commenting on this ne ... more

  • Companies

    Gilson International B.V.

    Gilson is a family-owned global manufacturer of liquid handling, purification and extraction solutions for the life sciences industry. We help researchers advance the pace of discovery by creating easy-to-use lab instruments that improve reproducibility and traceability. Since 1957, we hav ... more

    Gilson, Inc.

    The Gilson legacy began in the 1940s, when Dr. Warren Gilson, while a faculty member at the University of Wisconsin Medical School, began to design and develop specialized medical electronics and instruments that were not commercially available. One of his first efforts produced was a Catho ... more

    Gilson S.A.S.

    more