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Thioesters are compounds resulting from the bonding of sulfur with an acyl group with the general formula R-S-CO-R'. They are the product of esterification between a carboxylic acid and a thiol (as opposed to an alcohol in regular esters).
Thioesters and the origin of life
Some biochemists believe that the thioester bond was critical for the origin of life. One Nobel Prize winning scientist, Belgium's Christian de Duve, posits a "Thioester World," which preceded and developed into an "RNA World," itself the immediate precursor to the appearance of entities we would call organisms.
As de Duve explains:
Thionoesters are isomeric with thioesters. In a thionoester, sulfur replaces the carbonyl oxygen in an ester. Methylthionobenzoate is C6H5C(S)OCH3. Such compounds are typically prepared by the reaction of the thioacyl chloride with an alcohol, but they can also be made by the reaction of Lawesson's reagent with esters.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Thioester". A list of authors is available in Wikipedia.|