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Bemotrizinol



Bemotrizinol
IUPAC name 2,2'-[6-(4-Methoxyphenyl)-1,3,5-triazine-2,4-diyl]bis[5-[(2-ethylhexyl)oxy]phenol
Other names Tinosorb
Bis-ethylhexyloxyphenol methoxyphenyl triazine
Identifiers
Abbreviations BEMT
CAS number 187393-00-6
SMILES OC(C=C(OCC(CC)CCCC)C=C4)=C4C1=NC(C2=CC=C(OC)C=C2)=NC(C3=CC=C(OCC(CC)CCCC)C=C3O)=N1
Properties
Molecular formula C38H49N3O5
Molar mass 627.81
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references

Bemotrizinol (USAN[1], Tinosorb® S, INCI Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine) is an oil soluble chemical which is added to sunscreens to absorb UV rays. It's marketed by Ciba Specialty Chemicals. It is a broad spectrum UV absorber, absorbing UVB as well as UVA rays. Bemotrizinol is highly photostable. Even after 50 MED (minimal edemal dose) 98.4% remains intact. It helps prevent photodegradation of other sunscreen actives.[2]

Additional recommended knowledge

Bemotrizinol is not approved by the United States Food and Drug Administration, but is approved in the European Union since the year 2000[3] and other parts of the world, including Australia.[4][5]

Unlike some other organic sunscreen actives, it shows no estrogenic effects in vitro.[6]

See also

References

  1. ^ http://www.ama-assn.org/ama1/pub/upload/mm/365/bemotrizinol.doc
  2. ^ Chatelain E, Gabard B. (Sep 2001). "Photostabilization of Butyl methoxydibenzoylmethane (Avobenzone) and Ethylhexyl methoxycinnamate by Bis-ethylhexyloxyphenol methoxyphenyl triazine (Tinosorb S), a new UV broadband filter". Photochem Photobiol 74(3): 401-6. PMID 11594052.
  3. ^ http://www.springerlink.com/content/6myjq6qa8l52cegv
  4. ^ NEW-WAVE SUNSCREENS: Active ingredient makers are frustrated by the long list of sunscreens and UV-A testing protocols that are still awaiting FDA decisions, Chemical & Engineering News, April 11, 2005, Volume 83, Number 15, pp. 18-22. Online version
  5. ^ http://www.tga.gov.au/docs/pdf/argom_10.pdf
  6. ^ Ashby J, Tinwell H, Plautz J, Twomey K, Lefevre PA (Dec 2001). "Lack of binding to isolated estrogen or androgen receptors, and inactivity in the immature rat uterotrophic assay, of the ultraviolet sunscreen filters Tinosorb M-active and Tinosorb S". Regul Toxicol Pharmacol 34(3): 287-91. PMID 11754532.
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Bemotrizinol". A list of authors is available in Wikipedia.
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