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Bronidox



  Bronidox® (Registered Tradmark of Cognis Corp) is chemical compound 5-Bromo-5-Nitro-1,3-Dioxane. Its use on goods without license from Cognis is strictly prohibited.

  • Formula: C4H6BrNO4
  • Synonyms:
    • 5-Brom-5-Nitro-1,3-Dioxan
    • 5-Bromo-5-nitro-m-Dioxan or 5-Bromo-5-nitro-m-Dioxane
    • 1,3-Dioxane, 5-Bromo-5-Nitro-
    • BRONIDOX® L5
    • BRONIDOX® L
  • Molecular weight: 212.06.
  • Color:
    • white crystalline powder
    • colourless, transparent liquid in 1,2-propylene glycol
  • Melting point: 60 °C [1] or 58.5-62°C [2]
  • Light sensitive.
  • Solubility: insoluble in water
  • pH: 6-7
  • Stable under normal conditions
  • Non reactive with enzyme/substrate in assays but causes inhibition of enzyme activity n Bacteria [3]
  • BRONIDOX® L5 is corrosive on metals [4]
  •  ??? Incompabilities: strong oxidizing agents ??? [5]
  • CAS Number: 30007-47-7
  • EINECS Number: 250-001-7

Additional recommended knowledge

Contents

Used as

  • Stabilizer
  • Surfactant
  • It is used in immunology for preserving antibodies and antisera in 0.1 - 0.5% concentration. It is used as preservative to avoid use of sodium azide.
  • Bactericide. Very effective against yeast and fungi.
  • used in cosmetics since the mid-1970s as preservative for shampoos, foam bath, etc. Maximum concentration is 0.1 %.

Safety

  • Harmful
  • Harmful if swallowed R22
  • Toxic - tremor, convulsions, excitement
  • Irritating to skin R38 - dermatitis
  • wear suitable protective clothing S36
  • relatively non-toxic to mammals
  • some users do not recommend use in preparations destined for in vivo or tissue culture work [6]

Toxicology

according to FSASAX

  • Oral:
    • LD50, mouse, oral 590 mg/kg 24 hours
    • LD50, rat, oral 455 mg/kg 24 hours
    • LD50, rat, ipr. 31 mg/kg 24 hours
  • Skin:
    • LD50, mouse, skin 2500 µg/24 hours
    • LD50, rat, skin 2500 µg/24 hours

References

  • http://www.chemicon.com/webfiles/MSDS/ECM711msds.pdf (Safety data sheet and first aid)
  • http://www.chemicalland21.com/lifescience/phar/5-BROMO-5-NITRO-1,3-DIOXANE.htm
  • http://www.fitzchem.com/mfg_cogniscare.shtml
  • http://www.totalreproduction.com/products/specs/Bronidox.html
  • Mode of action of the antimicrobial compound 5-bromo-5-nitro-1,3-dioxane (bronidox)
  • http://www.labodia.com/en/intrinsic_factor/material_safety_data_sheet.pdf

See also

  • Bronopol = 2-Bromo-2-nitropropane-1,3-diol
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Bronidox". A list of authors is available in Wikipedia.
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