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Calcium carbimide

Calcium carbimide
Systematic (IUPAC) name
calcium 2-hydroxypropane-1,2,3-tricarboxylate; methylcyanamide
CAS number 8013-88-5
ATC code N07BB02
PubChem 6335910
Chemical data
Formula C6H8O7.CH2N2.Ca
Mol. mass 288.268 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.


Legal status
Routes  ?

Calcium carbimide, sold as the citrate salt under the trade name Temposil®, is an alcohol sensitizing agent. Its effects are similar to the drug disulfiram (Antabuse) in that it interferes with the normal metabolism of alcohol by preventing the breakdown of the metabolic byproduct acetaldehyde. The result is that when alcohol is consumed by users of calcium carbimide, they experience severe reactions which include symptoms such as sweating, difficulty breathing, rapid heartbeat, rash, nausea and vomiting, and headache.

While calcium carbimide is a good adjunct to other treatments for alcoholism, it has been found that, as with Antabuse, it is an ineffective therapy on its own, and many alcoholics will voluntarily discontinue the drug in order to continue drinking.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Calcium_carbimide". A list of authors is available in Wikipedia.
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