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Systematic (IUPAC) name
CAS number  ?
ATC code N07BC04
PubChem  ?
Chemical data
Formula C11H12Cl2N2O 
Mol. mass 259.131 g/mol
Pharmacokinetic data
Bioavailability >90%
Protein binding 80–90%
Metabolism Hepatic glucuronidation
Half life 11 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat.


Legal status


Routes Oral

Lofexidine is an alpha2-adrenergic receptor agonist, can be used as a short acting (short half life) anti-hypertensive, but mostly used to help with relief from symptoms of heroin or opiate withdrawal in opiate dependency. Used primarily in the United Kingdom [1]. See also clonidine.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Lofexidine". A list of authors is available in Wikipedia.
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