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Systematic (IUPAC) name
CAS number 396-01-0
ATC code C03DB02
PubChem 5546
DrugBank APRD00079
Chemical data
Formula C12H11N7 
Mol. mass 253.263 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 97%
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.


Legal status
Routes  ?

Triamterene (trade name Dyrenium) is a potassium-sparing diuretic used in combination with thiazide diuretics for the treatment of hypertension and edema. This medication is best avoided in patients with chronic kidney disease due to the possibility of hyperkalemia. People using this drug should use salt substitute very cautiously.[1]

Mode of action

Triamterene directly blocks the epithelial sodium channel (ENaC) on the lumen side of the kidney collecting tubule. Other diuretics cause an increase in the sodium concentrations in the forming urine causing more sodium to enter through ENaC, chasing more potassium out of the principal cell and into the forming urine. Blocking ENaC prevents this from happening. Amiloride works in the same way.

Side effects

Common side effects may include a depletion of sodium, folic acid and calcium, nausea, vomiting, diarrhea, headache, dizziness, fatigue, and dry mouth. Serious side effects may include heart palpitations, tingling/numbness, fever, chills, sore throat, rash, and back pain. Triamterene can also cause kidney stones through direct crystallization or by seeding calcium oxalate stones.


  1. ^ LoSalt Advisory Statement (PDF)
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Triamterene". A list of authors is available in Wikipedia.
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