Cicletanine


Cicletanine
Systematic (IUPAC) name
3-(4-Chloro-phenyl)-6-methyl-1,3-dihydro-furo[3,4-c]pyridin-7-ol
Identifiers
CAS number	89943-82-8
ATC code	C03BX03
PubChem	54910
Chemical data
Formula	C₁₄H₁₂Cl N O₂
Mol. mass	261.703 g/mol
SMILES	search in eMolecules, PubChem
Pharmacokinetic data
Bioavailability	?
Protein binding	97.3%
Metabolism	?
Half life	7.9 h
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status	℞-only(US)
Routes	Oral

Cicletanine is a furopyridine low-ceiling diuretic drug, usually used in the treatment of hypertension.^[1] The drug is manufactured by Ipsen and marketed by Recordati (in France) under the trade name Tenstaten.

References

^ Jean Sassard (1992), , John Libbey Eurotext, ISBN 086196313X,

v • d • e Antihypertensives (C02) and diuretics (C03)
Sympatholytic agents (including alpha)	centrally acting/antiadrenergics (Clonidine, Guanfacine, Methyldopa, Moxonidine, Rescinnamine, Reserpine, Rilmenidine) • ganglion-blocking/nicotinic antagonist (Mecamylamine, Trimethaphan) • peripherally acting/antiadrenergics (Prazosin, Guanethidine, Indoramin, Doxazosin)
Vasodilators	Diazoxide • Hydralazine • Minoxidil • Nitroprusside • Phentolamine
Other antihypertensives	serotonin antagonist (Ketanserin) • endothelin receptor antagonist (Bosentan, Ambrisentan, Sitaxsentan)
Low ceiling diuretics	Thiazide (Bendroflumethiazide, Chlorothiazide, Hydrochlorothiazide) • Chlortalidone • Indapamide • Quinethazone • Mersalyl • Metolazone • Theobromine • Cicletanine
High ceiling diuretics	Loop diuretic (Bumetanide, Furosemide, Torasemide)
Potassium-sparing diuretics	ESC blockers (Amiloride, Triamterene) • aldosterone antagonists (Spironolactone, Eplerenone, Potassium canrenoate, Canrenone)