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A sympatholytic is a medication which inhibits the functioning of the sympathetic nervous system (SNS). They are used as antihypertensives.
Additional recommended knowledge
Antiadrenergic agents inhibit the signals of adrenaline and noradrenaline. They are mainly adrenergic antagonists, inhibiting adrenergic receptors, but there are exceptions: clonidine is an adrenergic agonist on the α2 receptor, since this receptor is located presynaptically to inhibit further release of adrenaline and noradrenaline.
Other ways of inhibiting adrenergic signaling is by catecholamine synthesis blocking, e.g. by methyltyrosine. Reserpine works by inhibiting transport into synaptic vesicles of noradrenaline by inhibiting the VMAT transporter.
Many antiadrenergic agents used as antihypertensives include:
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Sympatholytic". A list of authors is available in Wikipedia.|