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Carboxylation in organic chemistry
Carboxylation in biochemistry
Carboxylation in biochemistry is a posttranslational modification of glutamate residues in proteins. It occurs primarily in proteins involved in the blood clotting cascade, specifically factors II, VII, IX, and X, protein C, and protein S, and also in some bone proteins. This modification is required for these proteins to function. Carboxylation occurs in the liver and is performed by γ-glutamyl carboxylase.
The carboxylase requires vitamin K as a cofactor and performs the reaction in a processive manner. γ-carboxyglutamate binds calcium, which is essential for its activity. For example, in prothrombin, calcium binding allows the protein to associate with the plasma membrane in platelets, bringing it into close proximity with the proteins that cleave prothrombin to active thrombin after injury.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Carboxylation". A list of authors is available in Wikipedia.|