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The Castro-Stephens Coupling is a cross coupling reaction between a Copper(I) acetylide and an aryl halide forming a disubstituted alkyne and a copper(I) halide.
Additional recommended knowledge
The reaction was discovered in 1963 by chemists Casto and Stephens   and is used as a tool in the organic synthesis of organic compounds. The reaction has similarities with the much older Rosenmund-von Braun synthesis (1916) between aryl halides and copper(I) cyanide and was itself modified in 1973 with as the Sonogashira coupling by adding a palladium catalyst and preparing the organocopper compound in situ.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Castro-Stephens_coupling". A list of authors is available in Wikipedia.