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Creatine ethyl ester

Creatine ethyl ester
IUPAC name Ethyl N-(aminoiminomethyl)-N-methylglycine
CAS number 15366-29-7
Molecular formula C6H13N3O2
Molar mass 159.19
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references

Creatine ethyl ester, also known as creatine ester, cre-ester and CEE, is a substance sold as an aid for athletic performance and for muscle development in bodybuilding. It is an ethyl ester derivative of creatine, from which it is made.[1] In the body, CEE is converted back into creatine. The ethyl ester is said to have a much better absorption rate and a longer half-life in the body than regular creatine monohydrate.[citation needed][dubious], because it is slightly more lipophilic. However, these claims have not yet been conclusively proven by independent research, and in fact a study presented at the 4th International Society of Sports Nutrition (ISSN) annual meeting demonstrated that that the addition of the ethyl group to creatine actually reduces acid stability and accelerates its breakdown to creatinine. The researchers concluded that creatine ethyl-ester is inferior to creatine monohydrate as a source of creatine.

As a supplement, the compound was developed, patented and licensed through UNeMed, the technology transfer entity of the University of Nebraska Medical Center, and is sold under numerous brand names.


  1. ^ *J. D. Mold, R. C. Gore, J. M. Lynch, E. J. Schantz (1955). "Creatine Ethyl Ether". Journal of the American Chemical Society 77 (1): 178 - 180. doi:10.1021/ja01606a060.
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Creatine_ethyl_ester". A list of authors is available in Wikipedia.
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