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Felodipine



Felodipine
Systematic (IUPAC) name
ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro
-2,6-dimethyl-3,5- pyridinedicarboxylate
Identifiers
CAS number 72509-76-3
ATC code C08CA02
PubChem 3333
DrugBank APRD00374
Chemical data
Formula C18H19Cl2NO4 
Mol. mass 383.069 g/mol
Pharmacokinetic data
Bioavailability >95% [1]
Metabolism Hepatic
Half life  ??
Excretion Renal
Therapeutic considerations
Pregnancy cat.

C(US)

Legal status

Prescription only

Routes Oral

Felodipine is a calcium channel blocker (calcium antagonist), a drug used to control hypertension (high blood pressure). It is marketed with the brand name Plendil by AstraZeneca.

Additional recommended knowledge

Interactions

Recent findings have suggested that felodipine in combination with grapefruit juice can cause abnormal (toxic) effects. Oral administration of Felodipine is first metabolized in the gastrointestinal tract (GI) and liver by CYP3A4. Grapefruit juice is found to have an inhibiting effect over cytochrome P450 3A4. As a result the bioavailability of the drug and area under the curve (AUC) increase, increasing the risk for abnormal side effects. Therefore, special caution must be taken when mixing grapefruit juice with Felodipine.

References

  1. ^ Blychert E. (1992). "Felodipine pharmacokinetics and plasma concentration vs effect relationships". Blood Press Suppl. 2: 1-30.
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Felodipine". A list of authors is available in Wikipedia.
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