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Recent findings have suggested that felodipine in combination with grapefruit juice can cause abnormal (toxic) effects. Oral administration of Felodipine is first metabolized in the gastrointestinal tract (GI) and liver by CYP3A4. Grapefruit juice is found to have an inhibiting effect over cytochrome P450 3A4. As a result the bioavailability of the drug and area under the curve (AUC) increase, increasing the risk for abnormal side effects. Therefore, special caution must be taken when mixing grapefruit juice with Felodipine.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Felodipine". A list of authors is available in Wikipedia.|