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Nicardipine



Nicardipine
Systematic (IUPAC) name
methyl2-(benzyl-methyl-amino)ethyl2,6-dimethyl-4- (3-nitrophenyl)-1,4-dihydropyridine- 3,5-dicarboxylate
Identifiers
CAS number 55985-32-5
ATC code C08CA04
PubChem 4474
DrugBank APRD00088
Chemical data
Formula C26H29N3O6 
Mol. mass 479.525 g/mol
Physical data
Melt. point 6 °C (43 °F)
Pharmacokinetic data
Bioavailability  ?
Protein binding >95%
Metabolism  ?
Half life 8.6 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

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Legal status
Routes  ?

Nicardipine hydrochloride (Cardene®) is a medication used to treat high blood pressure and angina. It belongs to the class of calcium channel blockers.

Additional recommended knowledge

Nicardipine is a dihydropyridine calcium-channel blocking agent used for the treatment of vascular disorders such as chronic stable angina, hypertension, and Raynaud's phenomenon. It is available in oral and intravenous formulations. Its mechanism of action and clinical effects closely resemble those of nifedipine and the other dihydropyridines (amlodipine, felodipine), except that nicardipine is more selective for cerebral and coronary blood vessels. Furthermore, nicardipine does not intrinsically decrease myocardial contractility and may be useful in the management of congestive heart failure. Nicardipine also has a longer half-life than nifedipine. Nicardipine was approved by the FDA in December 1988. The patent for both Cardene® and Cardene SR® expired in October 1995.

 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Nicardipine". A list of authors is available in Wikipedia.
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