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GDP-fucose protein O-fucosyltransferase 2
Additional recommended knowledge
GDP-fucose protein O-fucosyltransferase 2 (POFUT2) is an enzyme responsible for adding fucose sugars in O linkage to serine or threonine residues in Thrombospondin repeats. The protein is an inverting glycosyltransferase, which means that the enzyme uses GDP-β-L-fucose as a donor substrate and transfers the fucose in O linkage to the protein producing fucose-α-O-serine/threonine.
Almost all glycosyltransferases reside in the Golgi apparatus. However, POFUT2 as well as the related enzyme POFUT1 have recently been shown to reside in the endoplasmic reticulum.
Categories: Transferases | EC 2.4.1
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "GDP-fucose_protein_O-fucosyltransferase_2". A list of authors is available in Wikipedia.|