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Name of Symptom/Sign:
Iron overload disorder
Classifications and external resources
In medicine, iron overload disorders are diseases caused by the accumulation of iron in the body. Organs commonly affected are the liver, heart and endocrine glands.
Additional recommended knowledge
The causes can be distinguished between primary (generally genetic) and secondary (due to other conditions).
Primary iron overload
| Description || OMIM || Mutation
| Haemochromatosis type 1: "classical"-haemochromatosis || 235200 || HFE
| Haemochromatosis type 2A: juvenile haemochromatosis || 602390 || hemojuvelin ("HJV", also known as HFE2)
| Haemochromatosis type 2B: juvenile haemochromatosis || 606464 || hepcidin antimicrobial peptide (HAMP) or HFE2B
| Haemochromatosis type 3 || 604720 || transferrin receptor-2 (TFR2 or HFE3)
| Haemochromatosis type 4 || 604653 || ferroportin (SLC11A3)
| Neonatal haemochromatosis || 231100 || (unknown)
| Aceruloplasminaemia (rare disease) || 604290 || ceruloplasmin
| Congenital atransferrinaemia (rare disease) || 209300 || transferrin
Secondary iron overload
- Dietary iron overload
- Transfusional iron overload
- Long term haemodialysis
- Chronic liver disease
- Hepatitis C
- Alcoholic cirrhosis, especially when advanced
- Non-alcoholic steatohepatitis
- Porphyria cutanea tarda
- Post-portacaval shunting
- Dysmetabolic iron overload syndrome
The part-genetic, part-environmental syndrome known as African iron overload in sub-Sahara Africa (Online 'Mendelian Inheritance in Man' (OMIM) 601195)
- ^ Andrews NC (1999). "Disorders of iron metabolism". N. Engl. J. Med. 341 (26): 1986-95. PMID 10607817.
- ^ Pietrangelo A (2003). "Haemochromatosis". Gut 52 Suppl 2: ii23-30. PMID 12651879.
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Iron_overload_disorder". A list of authors is available in Wikipedia.
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