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Iron overload disorder

Name of Symptom/Sign:
Iron overload disorder
Classifications and external resources
ICD-10 R79.0
ICD-9 790.6

In medicine, iron overload disorders are diseases caused by the accumulation of iron in the body. Organs commonly affected are the liver, heart and endocrine glands.[1]



The causes can be distinguished between primary (generally genetic) and secondary (due to other conditions).[2]

Primary iron overload

Description OMIM Mutation
Haemochromatosis type 1: "classical"-haemochromatosis 235200 HFE
Haemochromatosis type 2A: juvenile haemochromatosis 602390 hemojuvelin ("HJV", also known as HFE2)
Haemochromatosis type 2B: juvenile haemochromatosis 606464 hepcidin antimicrobial peptide (HAMP) or HFE2B
Haemochromatosis type 3 604720 transferrin receptor-2 (TFR2 or HFE3)
Haemochromatosis type 4 604653 ferroportin (SLC11A3)
Neonatal haemochromatosis 231100 (unknown)
Aceruloplasminaemia (rare disease) 604290 ceruloplasmin
Congenital atransferrinaemia (rare disease) 209300 transferrin

Secondary iron overload

  • Dietary iron overload
  • Transfusional iron overload
  • Long term haemodialysis
  • Chronic liver disease
    • Hepatitis C
    • Alcoholic cirrhosis, especially when advanced
    • Non-alcoholic steatohepatitis
  • Porphyria cutanea tarda
  • Post-portacaval shunting
  • Dysmetabolic iron overload syndrome


The part-genetic, part-environmental syndrome known as African iron overload in sub-Sahara Africa (Online 'Mendelian Inheritance in Man' (OMIM) 601195)

See also


  1. ^ Andrews NC (1999). "Disorders of iron metabolism". N. Engl. J. Med. 341 (26): 1986-95. PMID 10607817.
  2. ^ Pietrangelo A (2003). "Haemochromatosis". Gut 52 Suppl 2: ii23-30. PMID 12651879.
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Iron_overload_disorder". A list of authors is available in Wikipedia.
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