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Low density lipoprotein receptor gene family
The low density lipoprotein receptor gene family code for a class of structurally closely related cell surface receptors that fulfill diverse biological functions in different organs, tissues, and cell types. The role that is most commonly associated with this evolutionarily ancient family is cholesterol homeostasis (maintenance of appropriate concentration of cholesterol). In humans, excess cholesterol in the blood is captured by low-density lipoprotein (LDL) and removed in the liver by the endocytosis of the LDL receptor. Recent evidence indicates that the members of the LDL receptor gene family are active in the cell signalling pathways between specialized cells in many, if not all, multicellular organisms.
Additional recommended knowledge
There are seven members of the LDLR family in mammals, namely:
The members of the LDLR family are characterized by distinct functional domains present in characteristic numbers. These modules are:
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Low_density_lipoprotein_receptor_gene_family". A list of authors is available in Wikipedia.