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MSin3 interaction domainTemplate:DISPLAYTITLE:mSin3 interaction domain Additional recommended knowledgeThe mSin3 interaction domain (SID) is present on several transcriptional repressor proteins including TGFβ (transforming growth factor β) and Mad. It interacts with the paired amphipathic alpha-helix 2 (PAH2) domain of mSin3, a transcriptional repressor domain attached to some transcription repressor proteins such as the mSin3A corepressor. Action of histone deacetylase 1 and 2 (HDAC1/2) is induced by the interaction of mSin3A with a multi-protein complex containing HDAC1/2. Transcription is also repressed by histone deacetylase-independent means.
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| This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "MSin3_interaction_domain". A list of authors is available in Wikipedia. |
