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Mexiletine



Mexiletine
Systematic (IUPAC) name
1-(2,6-dimethylphenoxy)propan-2-amine
Identifiers
CAS number 31828-71-4
ATC code C01BB02
PubChem 4178
DrugBank APRD00242
Chemical data
Formula C11H17NO 
Mol. mass 179.259 g/mol
Pharmacokinetic data
Bioavailability 90%
Protein binding 50-60%
Metabolism Hepatic (CYP2D6 and 1A2- mediated)
Half life 10-12 hours
Excretion Renal (10%)
Therapeutic considerations
Pregnancy cat.

B1(AU) C(US)

Legal status

POM(UK) -only(US)

Routes Oral, IV

Mexiletine (INN, sold under the trade name Mexitil®) belongs to the Class IB anti-arrhythmic group of medicines. It is used to treat arrhythmias within the heart - or seriously irregular heartbeats. It slows nerve impulses in the heart and makes the heart tissue less sensitive. Dizziness, heartburn, nausea, nervousness, trembling, unsteadiness are common side effects. It is available in injection and capsule form.

Additional recommended knowledge

Class IB antiarrhythmics decrease action potential duration by shortening the repolarization phase. This is achieved by blocking sodium channels[1].

Mexiletine may also be of use in patients experiencing refractory pain. (Sweetman, 2002) and is also effective for treating muscle stiffness resulting from myotonia congenita (Thomsen disease)

References

  • Peck T; Hill S, Williams M (eds.) (2004). Pharmacology for Anaesthesia and Intensive Care, 2nd ed., Cambridge University Press. ISBN 0-521-68794-2. 
  • Sweetman S (ed.) (2002). Martindale: The complete drug reference, 33rd ed., London: Pharmaceutical Press. ISBN 0-85369-499-0. 
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Mexiletine". A list of authors is available in Wikipedia.
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