Cytochrome P450, family 1, subfamily A, polypeptide 2
PDB rendering based on 2hi4.
Available structures: 2hi4
Identifiers
Symbol(s)
CYP1A2; CP12; P3-450; P450(PA)
External IDs
OMIM: 124060MGI: 88589Homologene: 68082
Gene Ontology
Molecular Function:
• iron ion binding • electron carrier activity • oxygen binding • heme binding • metal ion binding • unspecific monooxygenase activity
Cellular Component:
• endoplasmic reticulum • microsome • membrane
Biological Process:
• electron transport
RNA expression pattern
More reference expression data
Orthologs
Human
Mouse
Entrez
1544
13077
Ensembl
ENSG00000140505
ENSMUSG00000032310
Uniprot
P05177
P00186
Refseq
NM_000761 (mRNA) NP_000752 (protein)
NM_009993 (mRNA) NP_034123 (protein)
Location
Chr 15: 72.83 - 72.84 Mb
Chr 9: 57.48 - 57.48 Mb
Pubmed search
[1]
[2]
Cytochrome P450 1A2 (abbreviated CYP1A2), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body.
Expression of CYP1A2 appears to be induced by various dietary constituents.[1]
^ Fontana R, Lown K, Paine M, Fortlage L, Santella R, Felton J, Knize M, Greenberg A, Watkins P (1999). "Effects of a chargrilled meat diet on expression of CYP3A, CYP1A, and P-glycoprotein levels in healthy volunteers". Gastroenterology117 (1): 89-98. PMID 10381914.
^ ab Mentioned both in the reference named FASS and were previously mentioned in Wikipedia. Further contributions may follow other systems
^ Swedish environmental classification of pharmaceuticals Facts for prescribers (Fakta för förskrivare)
^ Edwards DJ, Bernier SM (1996). "Inhibitory effect of grapefruit juice and its bitter principal, naringenin, on CYP1A2 dependent metabolism of caffeine in man". Life Sciences59 (13): 1025-1030. PMID 8485024.
Meijerman I, Beijnen J, Schellens J. "Herb-drug interactions in oncology: focus on mechanisms of induction". Oncologist11 (7): 742-52. PMID 16880233.
Further reading
Smith G, Stubbins MJ, Harries LW, Wolf CR (1999). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily.". Xenobiotica28 (12): 1129-65. PMID 9890157.
Landi MT, Sinha R, Lang NP, Kadlubar FF (1999). "Human cytochrome P4501A2.". IARC Sci. Publ. (148): 173-95. PMID 10493258.
Nelson DR, Zeldin DC, Hoffman SM, et al. (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.". Pharmacogenetics14 (1): 1-18. PMID 15128046.
Ikeya K, Jaiswal AK, Owens RA, et al. (1990). "Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression.". Mol. Endocrinol.3 (9): 1399-408. PMID 2575218.
Butler MA, Iwasaki M, Guengerich FP, Kadlubar FF (1989). "Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.". Proc. Natl. Acad. Sci. U.S.A.86 (20): 7696-700. PMID 2813353.
Quattrochi LC, Okino ST, Pendurthi UR, Tukey RH (1986). "Cloning and isolation of human cytochrome P-450 cDNAs homologous to dioxin-inducible rabbit mRNAs encoding P-450 4 and P-450 6.". DNA4 (5): 395-400. PMID 3000715.
Quattrochi LC, Pendurthi UR, Okino ST, et al. (1986). "Human cytochrome P-450 4 mRNA and gene: part of a multigene family that contains Alu sequences in its mRNA.". Proc. Natl. Acad. Sci. U.S.A.83 (18): 6731-5. PMID 3462722.
Wrighton SA, Campanile C, Thomas PE, et al. (1986). "Identification of a human liver cytochrome P-450 homologous to the major isosafrole-inducible cytochrome P-450 in the rat.". Mol. Pharmacol.29 (4): 405-10. PMID 3517618.
Jaiswal AK, Nebert DW, McBride OW, Gonzalez FJ (1988). "Human P(3)450: cDNA and complete protein sequence, repetitive Alu sequences in the 3' nontranslated region, and localization of gene to chromosome 15.". J. Exp. Pathol.3 (1): 1-17. PMID 3681487.
Eugster HP, Probst M, Würgler FE, Sengstag C (1993). "Caffeine, estradiol, and progesterone interact with human CYP1A1 and CYP1A2. Evidence from cDNA-directed expression in Saccharomyces cerevisiae.". Drug Metab. Dispos.21 (1): 43-9. PMID 8095225.
Schweikl H, Taylor JA, Kitareewan S, et al. (1994). "Expression of CYP1A1 and CYP1A2 genes in human liver.". Pharmacogenetics3 (5): 239-49. PMID 8287062.
Yamazaki H, Inoue K, Mimura M, et al. (1996). "7-Ethoxycoumarin O-deethylation catalyzed by cytochromes P450 1A2 and 2E1 in human liver microsomes.". Biochem. Pharmacol.51 (3): 313-9. PMID 8573198.
Hakkola J, Raunio H, Purkunen R, et al. (1996). "Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnancy.". Biochem. Pharmacol.52 (2): 379-83. PMID 8694864.
Guengerich FP, Johnson WW (1998). "Kinetics of ferric cytochrome P450 reduction by NADPH-cytochrome P450 reductase: rapid reduction in the absence of substrate and variations among cytochrome P450 systems.". Biochemistry36 (48): 14741-50. doi:10.1021/bi9719399. PMID 9398194.
Wacke R, Kirchner A, Prall F, et al. (1998). "Up-regulation of cytochrome P450 1A2, 2C9, and 2E1 in chronic pancreatitis.". Pancreas16 (4): 521-8. PMID 9598815.
Macé K, Bowman ED, Vautravers P, et al. (1998). "Characterisation of xenobiotic-metabolising enzyme expression in human bronchial mucosa and peripheral lung tissues.". Eur. J. Cancer34 (6): 914-20. PMID 9797707.
Huang JD, Guo WC, Lai MD, et al. (1999). "Detection of a novel cytochrome P-450 1A2 polymorphism (F21L) in Chinese.". Drug Metab. Dispos.27 (1): 98-101. PMID 9884316.
Tatemichi M, Nomura S, Ogura T, et al. (1999). "Mutagenic activation of environmental carcinogens by microsomes of gastric mucosa with intestinal metaplasia.". Cancer Res.59 (16): 3893-8. PMID 10463577.
