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Systematic (IUPAC) name
CAS number 111406-87-2
ATC code  ?
PubChem 60490
DrugBank APRD00265
Chemical data
Formula C11H12N2O2S 
Mol. mass 236.291 g/mol
Pharmacokinetic data
Bioavailability Not yet established
Protein binding 93%
Metabolism Hepatic (CYP1A2, CYP2C9 and CYP3A4-mediated)
Half life 2.5 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat.


Legal status


Routes Oral

Zileuton (INN) is an asthma drug. It blocks leukotriene synthesis by inhibiting 5-lipoxygenase, an enzyme of the eicosanoid synthesis pathway.

Zileuton is marketed by Critical Therapeutics under the brand name Zyflo®.

See also

  • Lipoxygenase inhibitor

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Zileuton". A list of authors is available in Wikipedia.
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