My watch list

Zileuton



Zileuton
Systematic (IUPAC) name
1-(1-benzothiophen-2-ylethyl)-1-hydroxy-urea
Identifiers
CAS number	111406-87-2
ATC code	?
PubChem	60490
DrugBank	APRD00265
Chemical data
Formula	C₁₁H₁₂N₂O₂S
Mol. mass	236.291 g/mol
Pharmacokinetic data
Bioavailability	Not yet established
Protein binding	93%
Metabolism	Hepatic (CYP1A2, CYP2C9 and CYP3A4-mediated)
Half life	2.5 hours
Excretion	Renal
Therapeutic considerations
Pregnancy cat.	C(US)
Legal status	℞-only(US)
Routes	Oral

Zileuton (INN) is an asthma drug. It blocks leukotriene synthesis by inhibiting 5-lipoxygenase, an enzyme of the eicosanoid synthesis pathway.

Zileuton is marketed by Critical Therapeutics under the brand name Zyflo®.

v • d • e Drugs for obstructive airway diseases: asthma/COPD (R03)
Adrenergics, inhalants	Short acting β₂-agonists: Salbutamol/Levosalbutamol • Fenoterol • Terbutaline Long acting β₂-agonists (LABA): Bambuterol • Clenbuterol • Formoterol • Salmeterol other: Epinephrine • Isoproterenol • Orciprenaline
Glucocorticoids	Beclometasone • Budesonide • Ciclesonide • Fluticasone • Mometasone
Anticholinergics	Ipratropium • Tiotropium
Mast cell stabilizers	Cromoglicate • Nedocromil
Xanthines	Aminophylline • Theobromine • Theophylline
Leukotriene antagonists	Montelukast • Pranlukast • Zafirlukast
Combination products	Budesonide/formoterol • Fluticasone/salmeterol • Ipratropium/salbutamol