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CYP2C9

Cytochrome P450, family 2, subfamily C, polypeptide 9

Ribbon diagram of CYP2C9, heme group visible at center. From PDB 1OG2.

Available structures: 1og2, 1og5, 1r9o

Identifiers

Symbol(s)

CYP2C9; CYP2C; CPC9; CYP2C10; MGC149605; MGC88320; P450 MP-4; P450 PB-1; P450IIC9

External IDs

OMIM: 601130 MGI: 103238 Homologene: 86657

Gene Ontology
Molecular Function:	• iron ion binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen • (S)-limonene 6-monooxygenase activity • (S)-limonene 7-monooxygenase activity • heme binding • metal ion binding
Cellular Component:	• endoplasmic reticulum • microsome • membrane
Biological Process:	• electron transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Entrez

1559

13095

Ensembl

ENSG00000138109

ENSMUSG00000003053

Uniprot

P11712

Q3UEF2

Refseq

NM_000771 (mRNA)
NP_000762 (protein)

NM_007815 (mRNA)
NP_031841 (protein)

Location

Chr 10: 96.69 - 96.74 Mb

Chr 19: 39.34 - 39.38 Mb

Pubmed search

[1]

[2]

Cytochrome P450 2C9 (abbreviated CYP2C9), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body. It is involved in the metabolism of several important groups of drugs including many non-steroidal anti-inflammatory drugs (NSAIDs) and sulfonylureas.

Genetic polymorphism exists for CYP2C9 expression, with approximately 1–3% of Caucasian populations being poor metabolisers with no CYP2C9 function.

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CYP2C9 Ligands

**Selected inducers, inhibitors and substrates of CYP2C9^[1]**
Substrates	Inhibitors	Inducers
Often mentioned ^[2]: NSAIDs (analgesic, antipyretic, anti-inflammatory) celecoxib diclofenac ibuprofen naproxen piroxicam meloxicam phenytoin (antiepileptic) fluvastatin (statin) sulfonylurea (antidiabetic) glibenclamide glimepiride glipizide tolbutamide angiotensin II receptor antagonists (in hypertension, diabetic nephropathy, CHF) irbesartan losartan S-warfarin (anticoagulant) Other: sildenafil (in erectile dysfunction) terbinafine (antifungal) miconazole (antifungal) amitriptyline (tricyclic antidepressant) pitavastatin (statin) rosiglitazone (antidiabetic) tamoxifen (SERM) cannabinoids (psychoactive)	Strong ^[3]: sulfaphenazole (antibacterial) fluconazole (antifungal) Valproic acid (anticonvulsant, mood-stabilizing) others: amiodarone (antiarrhythmic) cimetidine (H2-receptor antagonist) fenofibrate (fibrate) fluvastatin (statin) fluvoxamine (SSRI) isoniazid (in tuberculosis) lovastatin (statin) probenecid (uricosuric) sertraline (SSRI) sulfamethoxazole (antibiotic) teniposide (chemotherapeutic) voriconazole (antifungal) zafirlukast (leukotriene antagonist)	Often mentioned ^[2]: rifampicin (bactericidal) Other: hyperforin (constituent of St John's Wort) secobarbital (barbiturate)

References

^ Where classes of agents are listed, there may be exceptions within the class
^ ^a ^b Mentioned both in the reference named FASS and were previously mentioned in Wikipedia. Further contributions may follow other systems
^ Swedish environmental classification of pharmaceuticals Facts for prescribers (Fakta för förskrivare)

Goldstein JA, de Morais SM (1995). "Biochemistry and molecular biology of the human CYP2C subfamily.". Pharmacogenetics 4 (6): 285-99. PMID 7704034.
Miners JO, Birkett DJ (1998). "Cytochrome P4502C9: an enzyme of major importance in human drug metabolism.". British journal of clinical pharmacology 45 (6): 525-38. PMID 9663807.
Smith G, Stubbins MJ, Harries LW, Wolf CR (1999). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily.". Xenobiotica 28 (12): 1129-65. PMID 9890157.
Henderson RF (2001). "Species differences in the metabolism of olefins: implications for risk assessment.". Chem. Biol. Interact. 135-136: 53-64. PMID 11397381.
Xie HG, Prasad HC, Kim RB, Stein CM (2003). "CYP2C9 allelic variants: ethnic distribution and functional significance.". Adv. Drug Deliv. Rev. 54 (10): 1257-70. PMID 12406644.
Palkimas MP, Skinner HM, Gandhi PJ, Gardner AJ (2004). "Polymorphism induced sensitivity to warfarin: a review of the literature.". J. Thromb. Thrombolysis 15 (3): 205-12. doi:10.1023/B:THRO.0000011376.12309.af. PMID 14739630.
Daly AK, Aithal GP (2004). "Genetic regulation of warfarin metabolism and response.". Seminars in vascular medicine 3 (3): 231-8. doi:10.1055/s-2003-44458. PMID 15199455.
García-Martín E, Martínez C, Ladero JM, Agúndez JA (2007). "Interethnic and intraethnic variability of CYP2C8 and CYP2C9 polymorphisms in healthy individuals.". Molecular diagnosis & therapy 10 (1): 29-40. PMID 16646575.

v • d • e Cytochromes, oxygenases: cytochrome P450 (EC 1.14)
CYP1	A1, A2, B1
CYP2	A6, A7, A13, B6, C8, C9, C18, C19, D6, E1, F1, J2, R1, S1, U1, W1
CYP3	A4, A5, A7, A43
CYP4	A11, A22, B1, F2, F3, F8, F11, F12, F22, V2, X1, Z1
CYP5-20	CYP5 (A1) - CYP7 (A1, B1) - CYP8 (A1, B1) - CYP11 (A1, B1, B2) - CYP17 (A1) - CYP19 (A1) - CYP20 (A1)
CYP21-51	CYP21 (A2) - CYP24 (A1) - CYP26 (A1, B1, C1) - CYP27 (A1, B1, C1) - CYP39 (A1) - CYP46 (A1) - CYP51 (A1)

Categories: Human proteins | Cytochrome P450

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "CYP2C9". A list of authors is available in Wikipedia.

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Contents

CYP2C9 Ligands

See also

References

Further reading

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