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CYP2C9




Cytochrome P450, family 2, subfamily C, polypeptide 9
Ribbon diagram of CYP2C9, heme group visible at center. From PDB 1OG2.
Available structures: 1og2, 1og5, 1r9o
Identifiers
Symbol(s) CYP2C9; CYP2C; CPC9; CYP2C10; MGC149605; MGC88320; P450 MP-4; P450 PB-1; P450IIC9
External IDs OMIM: 601130 MGI: 103238 Homologene: 86657
RNA expression pattern

More reference expression data

Orthologs
Human Mouse
Entrez 1559 13095
Ensembl ENSG00000138109 ENSMUSG00000003053
Uniprot P11712 Q3UEF2
Refseq NM_000771 (mRNA)
NP_000762 (protein) 		NM_007815 (mRNA)
NP_031841 (protein)
Location Chr 10: 96.69 - 96.74 Mb Chr 19: 39.34 - 39.38 Mb
Pubmed search [1] [2]

Cytochrome P450 2C9 (abbreviated CYP2C9), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body. It is involved in the metabolism of several important groups of drugs including many non-steroidal anti-inflammatory drugs (NSAIDs) and sulfonylureas.

Genetic polymorphism exists for CYP2C9 expression, with approximately 1–3% of Caucasian populations being poor metabolisers with no CYP2C9 function.

Contents

CYP2C9 Ligands

Selected inducers, inhibitors and substrates of CYP2C9[1]
Substrates Inhibitors Inducers
Often mentioned [2]:

Other:

Strong [3]:


others:

Often mentioned [2]:

Other:

See also

References

  1. ^ Where classes of agents are listed, there may be exceptions within the class
  2. ^ a b Mentioned both in the reference named FASS and were previously mentioned in Wikipedia. Further contributions may follow other systems
  3. ^ Swedish environmental classification of pharmaceuticals Facts for prescribers (Fakta för förskrivare)

Further reading

  • Goldstein JA, de Morais SM (1995). "Biochemistry and molecular biology of the human CYP2C subfamily.". Pharmacogenetics 4 (6): 285-99. PMID 7704034.
  • Miners JO, Birkett DJ (1998). "Cytochrome P4502C9: an enzyme of major importance in human drug metabolism.". British journal of clinical pharmacology 45 (6): 525-38. PMID 9663807.
  • Smith G, Stubbins MJ, Harries LW, Wolf CR (1999). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily.". Xenobiotica 28 (12): 1129-65. PMID 9890157.
  • Henderson RF (2001). "Species differences in the metabolism of olefins: implications for risk assessment.". Chem. Biol. Interact. 135-136: 53-64. PMID 11397381.
  • Xie HG, Prasad HC, Kim RB, Stein CM (2003). "CYP2C9 allelic variants: ethnic distribution and functional significance.". Adv. Drug Deliv. Rev. 54 (10): 1257-70. PMID 12406644.
  • Palkimas MP, Skinner HM, Gandhi PJ, Gardner AJ (2004). "Polymorphism induced sensitivity to warfarin: a review of the literature.". J. Thromb. Thrombolysis 15 (3): 205-12. doi:10.1023/B:THRO.0000011376.12309.af. PMID 14739630.
  • Daly AK, Aithal GP (2004). "Genetic regulation of warfarin metabolism and response.". Seminars in vascular medicine 3 (3): 231-8. doi:10.1055/s-2003-44458. PMID 15199455.
  • García-Martín E, Martínez C, Ladero JM, Agúndez JA (2007). "Interethnic and intraethnic variability of CYP2C8 and CYP2C9 polymorphisms in healthy individuals.". Molecular diagnosis & therapy 10 (1): 29-40. PMID 16646575.
v • d • e
Cytochromes, oxygenases: cytochrome P450 (EC 1.14)
CYP1A1, A2, B1
CYP2A6, A7, A13, B6, C8, C9, C18, C19, D6, E1, F1, J2, R1, S1, U1, W1
CYP3A4, A5, A7, A43
CYP4A11, A22, B1, F2, F3, F8, F11, F12, F22, V2, X1, Z1
CYP5-20CYP5 (A1) - CYP7 (A1, B1) - CYP8 (A1, B1) - CYP11 (A1, B1, B2) - CYP17 (A1) - CYP19 (A1) - CYP20 (A1)
CYP21-51CYP21 (A2) - CYP24 (A1) - CYP26 (A1, B1, C1) - CYP27 (A1, B1, C1) - CYP39 (A1) - CYP46 (A1) - CYP51 (A1)
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "CYP2C9". A list of authors is available in Wikipedia.
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