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cytochrome P450, family 2, subfamily E, polypeptide 1
Symbol CYP2E1
Alt. Symbols CYP2E
Entrez 1571
HUGO 2631
OMIM 124040
RefSeq NM_000773
UniProt P05181
Other data
Locus Chr. 10 q24.3-qter

Cytochrome P450 2E1 (abbreviated CYP2E1, EC, a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body. While it is involved only in the oxidative metabolism of a small range of substrates (mostly small polar molecules), there are many important drug interactions mediated by CYP2E1.


CYP2E1 Ligands

Selected inducers, inhibitors and substrates of CYP2E1[1]
Substrates Inhibitors Inducers
Often mentioned: [2]


Strong: [3]


Regulation of CYP2E1

Within one day of birth, the rat hepatic CYP2E1 gene is activated transcriptionally. CYP2E1 expression is easily inducible. It seems that there exist two stages of induction, a posttranslational mechanism for increased protein stability at low levels of ethanol, and an additional transciptional induction at high levels of ethanol[4]

See also


  1. ^ Where classes of agents are listed, there may be exceptions within the class
  2. ^ Mentioned both in the reference named FASS and were previously mentioned in Wikipedia. Further contributions may follow other systems
  3. ^ Swedish environmental classification of pharmaceuticals Facts for prescribers (Fakta för förskrivare)
  4. ^ Charles S. Lieber. 1999. Microsomal Ethanol-Oxidizing System (MEOS) The First 30 Years (1968-1998)-A Review. Alcoholism: Clinical and Experimental Research 23(6):991-1007
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "CYP2E1". A list of authors is available in Wikipedia.
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