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Cytochrome P450 2E1 (abbreviated CYP2E1, EC 188.8.131.52), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body. While it is involved only in the oxidative metabolism of a small range of substrates (mostly small polar molecules), there are many important drug interactions mediated by CYP2E1.
Additional recommended knowledge
Regulation of CYP2E1
Within one day of birth, the rat hepatic CYP2E1 gene is activated transcriptionally. CYP2E1 expression is easily inducible. It seems that there exist two stages of induction, a posttranslational mechanism for increased protein stability at low levels of ethanol, and an additional transciptional induction at high levels of ethanol
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "CYP2E1". A list of authors is available in Wikipedia.|