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Cholesterol 7 alpha-hydroxylase

cytochrome P450, family 7, subfamily A, polypeptide 1
Symbol CYP7A1
Alt. Symbols CYP7
Entrez 1581
HUGO 2651
OMIM 118455
RefSeq NM_000780
UniProt P22680
Other data
EC number
Locus Chr. 8 q11-q12

Cholesterol 7 alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in the synthesis of bile acid from cholesterol, catalyzing the formation of 7-alpha-hydroxycholesterol.

It is downregulated by Sterol regulatory element binding proteins (SREBP) when plasma cholesterol levels are low. It is upregulated by the nuclear receptor LXR (liver X receptor) when cholesterol (specifically - oxysterol) levels are high.[1] The effect of this upregulation is to increase the production of bile acids and reduce the level of cholesterol in hepatocytes.


  1. ^ Chawla A, Saez E, Evans RM (2000). "Don't know much bile-ology". Cell 103: 1–4.
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Cholesterol_7_alpha-hydroxylase". A list of authors is available in Wikipedia.
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