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Systematic (IUPAC) name
CAS number 36322-90-4
ATC code M01AC01 M02AA07, S01BC06
PubChem 5280452
DrugBank APRD01187
Chemical data
Formula C15H13N3O4S 
Mol. mass 331.348 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism 4 to 10% renal
Half life 30 to 86 hours
Excretion 4 to 10% renal
Therapeutic considerations
Pregnancy cat.

C, D if used in the third trimester or near delivery

Legal status
Routes  ?

Piroxicam (marketed in the U.S. under the trade name Feldene) is a non-steroidal anti-inflammatory drug used to relieve the symptoms of rheumatoid and osteoarthritis, primary dysmenorrhoea, postoperative pain; and act as an analgesic, especially where there is an inflammatory component. It is also used in veterinary medicine to treat certain neoplasias expressing cyclooxygenase (COX) receptors, such as bladder, colon, and prostate cancers.

Other brand names for Piroxicam include "Brexin," "Erazon," "Felden", "Feldoral," "Hotemin," "Pirox von ct," "Proponol," "Reumador," "Veral," and "Vurdon."

Mechanism of action

Main article: Non-steroidal anti-inflammatory drug

Piroxicam is an NSAID and, as such, is a non-selective COX inhibitor possessing both analgesic and antipyretic properties. It undergoes entero-hepatic circulation.

Adverse effects

Main article: Non-steroidal anti-inflammatory drug

Piroxicam use can result in gastrointestinal toxicity, tinnitus, dizziness, headache, rash, and pruritus. The most severe adverse reactions are peptic ulceration and gastrointestinal bleeding. Approximately 30% of all patients receiving daily doses of 20 mg of piroxicam experience side effects.[1]

Piroxicam may cause skin to become more sensitive to sunlight. Avoidance of sunlight and use of sunscreen is recommended.[citation needed]

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Piroxicam". A list of authors is available in Wikipedia.
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