My watch list
my.chemeurope.com  
Login  

Indoprofen



Indoprofen
Systematic (IUPAC) name
2-[4-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)
phenyl]propanoic acid
Identifiers
CAS number 31842-01-0
ATC code M01AE10
PubChem 3718
Chemical data
Formula C17H15NO3 
Mol. mass 281.306 g/mol
Pharmacokinetic data
Bioavailability High (rapid and complete absorption)
Metabolism Glucuronidation
Half life 2.3 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat.

?

Legal status

Withdrawn

Routes Oral

Indoprofen is a non-steroidal anti-inflammatory drug. It was withdrawn worldwide in the 1980s after postmarketing reports of severe gastrointestinal bleeding.[1]

Additional recommended knowledge

A 2004 study using high-throughput screening found indoprofen to increase production of the survival of motor neuron protein, suggesting it may provide insight into treatments for spinal muscular atrophies.[1][2]

References

  1. ^ a b Frazin, Natalie (March 9 2005). Pain Reliever May Provide Clues for Treating Spinal Muscular Atrophy. United States National Institute of Neurological Disorders and Stroke. Retrieved on 2007-10-06.
  2. ^ Lunn MR, Root DE, Martino AM, et al (2004). "Indoprofen upregulates the survival motor neuron protein through a cyclooxygenase-independent mechanism". Chem Biol 11 (11): 1489–93. doi:10.1016/j.chembiol.2004.08.024. PMID 15555999.


 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Indoprofen". A list of authors is available in Wikipedia.
Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE