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Indoprofen



Indoprofen
Systematic (IUPAC) name
2-[4-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)
phenyl]propanoic acid
Identifiers
CAS number 31842-01-0
ATC code M01AE10
PubChem 3718
Chemical data
Formula C17H15NO3 
Mol. mass 281.306 g/mol
Pharmacokinetic data
Bioavailability High (rapid and complete absorption)
Metabolism Glucuronidation
Half life 2.3 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat.

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Legal status

Withdrawn

Routes Oral

Indoprofen is a non-steroidal anti-inflammatory drug. It was withdrawn worldwide in the 1980s after postmarketing reports of severe gastrointestinal bleeding.[1]

A 2004 study using high-throughput screening found indoprofen to increase production of the survival of motor neuron protein, suggesting it may provide insight into treatments for spinal muscular atrophies.[1][2]

References

  1. ^ a b Frazin, Natalie (March 9 2005). Pain Reliever May Provide Clues for Treating Spinal Muscular Atrophy. United States National Institute of Neurological Disorders and Stroke. Retrieved on 2007-10-06.
  2. ^ Lunn MR, Root DE, Martino AM, et al (2004). "Indoprofen upregulates the survival motor neuron protein through a cyclooxygenase-independent mechanism". Chem Biol 11 (11): 1489–93. doi:10.1016/j.chembiol.2004.08.024. PMID 15555999.


v • d • e
Anti-inflammatory and antirheumatic products (M01)
Anti-inflammatory and
antirheumatic products, non-steroids		Butylpyrazolidines (Phenylbutazone, Mofebutazone, Oxyphenbutazone, Clofezone, Kebuzone)

Acetic acid derivatives and related substances (Indometacin, Sulindac, Tolmetin, Zomepirac, Diclofenac, Alclofenac, Bumadizone, Etodolac, Lonazolac, Fentiazac, Acemetacin, Difenpiramide, Oxametacin, Proglumetacin, Ketorolac, Aceclofenac, Bufexamac)

Oxicams (Piroxicam, Tenoxicam, Droxicam, Lornoxicam, Meloxicam)

Propionic acid derivatives (Ibuprofen, Naproxen, Ketoprofen, Fenoprofen, Fenbufen, Benoxaprofen, Suprofen, Pirprofen, Flurbiprofen, Indoprofen, Tiaprofenic acid, Oxaprozin, Ibuproxam, Dexibuprofen, Flunoxaprofen, Alminoprofen, Dexketoprofen)

Fenamates (Mefenamic acid, Tolfenamic acid, Flufenamic acid, Meclofenamic acid)

Coxibs (Celecoxib, Rofecoxib, Valdecoxib, Parecoxib, Etoricoxib, Lumiracoxib)

other anti-inflammatory and antirheumatic agents, non-steroids (Nabumetone, Niflumic acid, Azapropazone, Glucosamine, Benzydamine, Glucosaminoglycan polysulfate, Proquazone, Orgotein, Nimesulide, Feprazone, Diacerein, Morniflumate, Tenidap, Oxaceprol, Chondroitin sulfate)
Specific antirheumatic agentsQuinolines (Oxycinchophen) - Gold preparations (Sodium aurothiomalate, Sodium aurothiosulfate, Auranofin, Aurothioglucose, Aurotioprol) - Penicillamine/Bucillamine
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Indoprofen". A list of authors is available in Wikipedia.
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