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Tolmetin



Tolmetin
Systematic (IUPAC) name
2-[1-methyl-5-(4-methylbenzoyl)-pyrrol-2-yl]acetic acid
Identifiers
CAS number 26171-23-3
ATC code M01AB03 M02AA21
PubChem 5509
DrugBank APRD01268
Chemical data
Formula C15H15N3O3 
Mol. mass 257.285 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life 1-2 hours, next phase up to 5 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes oral

Tolmetin (IPA: /ˈtɒlmətɨn/) is a non-steroidal anti-inflammatory drug of the arylalkanoic acids. It is used primarily to reduce hormones that cause pain, swelling, tenderness, and stiffness in conditions such as osteoarthritis and rheumatoid arthritis, including juvenile rheumatoid arthritis. In the United States it is marketed as Tolectin and comes as a tablet or capsule.

Additional recommended knowledge

Tolmetin can increase the risk of heart or circulatory conditions such as heart attacks and strokes. It should not be taken shortly before or after coronary artery bypass surgery.[1] Tolmetin can also increase the risk of gastrointestinal conditions such as perforation or bleeding, which is fatal. Antacids can be taken with tolmetin to relieve stomachaches that often occur.[1] Overdose can result in drowsiness, nausea, epigastric pain, and vomiting.

When tested in rats tolmetin prevented experimentally stimulated polyarthritis and reduced inflammation. In patients with rheumatoid arthritis or osteoarthritis tolmetin restrained disease activity as efficiently as aspirin and indometacin, although the occurrence of mild gastrointestinal adverse effects and tinnitus was lower in patients treated with tolmetin than it was with aspirin-treated patients and the occurrence of adverse effects of the central nervous system was lower with tolmetin than it was with indometacin.[2]

Although the mechanism of action of tolmetin is unknown, research involving humans and animals has shown that tolmetin does not achieve anti-inflammatory response by stimulation of the adrenal or pituitary gland, but it has shown tolmetin restrains prostaglandin synthetase in vitro and reduces plasma of prostaglandin E, possibly causing the anti-inflammatory response.

References

  1. ^ a b Tolmetin. MedlinePlus. Retrieved on 2007-07-02.
  2. ^ Tolmetin. DrugBank. Retrieved on 2007-07-02.



 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Tolmetin". A list of authors is available in Wikipedia.
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