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Proglumetacin



Proglumetacin
Systematic (IUPAC) name
3-[4-[2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-
methylindol-3-yl]acetyl]oxyethyl]piperazin-1-yl]
propyl 4-(benzoylamino)-5-(dipropylamino)-
5-oxopentanoate
Identifiers
CAS number 57132-53-3
59209-40-4 (maleate)
ATC code M01AB14
PubChem 4921
Chemical data
Formula C46H58ClN5O8 
Mol. mass 844.43442 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism Hepatic. Undergoes enterohepatic recirculation
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes  ?

Proglumetacin (usually as the maleate salt, trade names Afloxan, Protaxon and Proxil) is a non-steroidal anti-inflammatory drug. It is metabolized in the body to indometacin and proglumide,[1] a drug with antisecretory effects that helps prevent injury to the stomach lining.

Additional recommended knowledge

References

  1. ^ Setnikar I, Arigoni R, Chisté R, Makovec F, Revel L (1987). "Plasma levels of proglumetacin and its metabolites after intravenous or oral administration in the dog". Arzneimittel-Forschung 37 (6): 698–702. PMID 3663267.


 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Proglumetacin". A list of authors is available in Wikipedia.
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