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Nafcillin



Nafcillin
Systematic (IUPAC) name
7-[(2-ethoxynaphthalen-1-yl) carbonylamino]- 3,3-dimethyl-6-oxo-2-thia-5-azabicyclo [ 3.2.0] heptane-4-carboxylic acid
Identifiers
CAS number 985-16-0
ATC code  ?
PubChem 8982
DrugBank APRD01130
Chemical data
Formula C21H22N2O5S 
Mol. mass 414.476 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 90%
Metabolism <30% hepatic
Half life  ?
Excretion Biliary and renal
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes IM, IV

Nafcillin sodium is a narrow spectrum beta-lactam antibiotic of the penicillin class. As a beta-lactamase-resistant penicillin, it is used to treat infections caused by Gram-positive bacteria, particularly species of Staphylococci, that are resistant to other penicillins.

Additional recommended knowledge

Side effects

As with all penicillins, serious life-threatening allergic reactions can occur.

Milder side effects include:

  • Nausea and vomiting
  • Diarrhea, often due to suppression of normal gastrointestinal bacteria. Occasionally, this leads to a more serious super-infection with an organism like Clostridium difficile
  • Abdominal pain
  • Yeast infections (thrush) affecting the mouth and tongue or vagina


 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Nafcillin". A list of authors is available in Wikipedia.
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