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N-type calcium channel

calcium channel, voltage-dependent, N type, alpha 1B subunit
Symbol CACNA1B
Alt. Symbols CACNL1A5
Entrez 774
HUGO 1389
OMIM 601012
RefSeq NM_000718
UniProt Q00975
Other data
Locus Chr. 9 q34

  The N-type calcium channel is a type of voltage-dependent calcium channel. Like the others of this class, the α1 subunit is the one that determines most of the channel's properties.

N-type ('N' for "Neural-Type"[1]) calcium channels are found primarily at presynaptic terminals and are involved in neurotransmitter release. Strong depolarization by an action potential causes these channels to open and allow influx of Ca2+, initiating vesicle fusion and release of stored neurotransmitter. N-type channels are blocked by ω-conotoxin.

The analgesic drug ziconotide inhibits N-type channels.


  1. ^ MeSH N-Type+Calcium+Channel
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "N-type_calcium_channel". A list of authors is available in Wikipedia.
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