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SK channel




Small conductance (SK) calcium-activated potassium channels are a type of Ca2+-activated K+ channels. SK channels, apparently voltage insensitive, are gated by submicromolar-levels of intracellular Ca2+ ions and are important for regulating afterhyperpolarization in central neurones and other cell types.

Additional recommended knowledge

SK channels are thought to be involved in synaptic plasticity and can be pharmacologically blocked by a plant-derived neurotoxin Bicuculline

The SK channel family contains 3 members - Sk1, SK2 and SK3.

All cloned SK channels, SK1, SK2 and SK3 are sensitive to the bee venom apamin and the scorpion venom tamapin.

Several SK channel family subunits were cloned (See for example Dr. John Adelman http://www.ohsu.edu/vollum/faculty/adelman/

Classification

  • Kca2.x : Kca2.1 (KCNN1), Kca2.2 (KCNN2), Kca2.3 (KCNN3)
  • Kca3.x: Kca3.1 (KCNN4)
  • Kca4.x: Kca4.1 (KCNT1), Kca4.2 (KCNT2)


 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "SK_channel". A list of authors is available in Wikipedia.
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