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Tandem pore domain potassium channel
Two-pore-domain potassium channels: This family of 15 members form what is known as "leak channels" which possess Goldman-Hodgkin-Katz (open) rectification. These channels are regulated by several mechanisms including oxygen tension, pH, mechanical stretch, and G-proteins. Their name is derived from the fact that the α subunits consist of four transmembrane segments, each containing two pore loops. As such, they structurally correspond to two inward-rectifier α subunits and thus form dimers in the membrane.
Additional recommended knowledge
Below is a list of the 15 known two-pore-domain human potassium channels:
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Tandem_pore_domain_potassium_channel". A list of authors is available in Wikipedia.|