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Sodium orthovanadate

Sodium orthovanadate
Systematic name Sodium orthovanadate
Other names sodium vanadate (V),
sodium vanadium oxide
Molecular formula Na3VO4
Molar mass 183.91 g/mol
Appearance white powder
CAS number [13721-39-6]
Density and phase 2.16 g/cm³, solid
Solubility in water soluble
Melting range 850-866°C
MSDS External MSDS
Main hazards Harmful.
NFPA 704
Flash point Non-flammable
RTECS number YW1120000
Except where noted otherwise, data are given for
materials in their standard state (at 25 °C, 100 kPa)
Infobox disclaimer and references

Sodium orthovanadate is an inhibitor of protein tyrosine phosphatases, alkaline phosphatases and a number of ATPases, most likely acting as a phosphate analogue. The VO43- ion binds irreversibly to the active sites of most protein tyrosine phosphatases.

It is often added to buffer solutions that are used in protein analysis in molecular biology. The aim is to preserve the phosphorylation of proteins of interest by inhibiting endogenous phosphatases present in cell lysate mixture. It is commonly used at a final concentration of 10 - 100mM. It is toxic when inhaled, swallowed or in contact with skin.


Swarup, G. et al. Biochem. Biophys. Res. Comm. 107: 1104-1109 (1982).

See also

  • Sodium metavanadate
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Sodium_orthovanadate". A list of authors is available in Wikipedia.
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