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Sodium orthovanadate is an inhibitor of protein tyrosine phosphatases, alkaline phosphatases and a number of ATPases, most likely acting as a phosphate analogue. The VO43- ion binds irreversibly to the active sites of most protein tyrosine phosphatases.
Additional recommended knowledge
It is often added to buffer solutions that are used in protein analysis in molecular biology. The aim is to preserve the phosphorylation of proteins of interest by inhibiting endogenous phosphatases present in cell lysate mixture. It is commonly used at a final concentration of 10 - 100mM. It is toxic when inhaled, swallowed or in contact with skin.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Sodium_orthovanadate". A list of authors is available in Wikipedia.|