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Wormlike chainThe wormlike chain (WLC) model in polymer physics is used to describe the behavior of semiflexible polymers; it is sometimes referred to as the KratkyPorod wormlike chain model. Additional recommended knowledge
Theoretical ConsiderationsThe WLC model envisions an isotropic rod that is continuously flexible; this is in contrast to the freelyjointed chain model that is flexible only between discrete segments. The wormlike chain model is particularly suited for describing stiffer polymers, with successive segments displaying a sort of cooperativity: all pointing in roughly the same direction. At room temperature, the polymer adopts a conformational ensemble that is smoothly curved; at T = 0 K, the polymer adopts a rigid rod conformation. For a polymer of length l, parametrize the path of the polymer as , allow to be the unit tangent vector to the chain at s, and to be the position vector along the chain. Then
It can be shown that the orientation correlation function for a wormlike chain follows an exponential decay:
where P is by definition the polymer's characteristic persistence length. A useful value is the mean square endtoend distance of the polymer:
Biological RelevanceSeveral biologically important polymers can be effectively modeled as wormlike chains, including: Stretching Wormlike Chain PolymersLaboratory tools such as atomic force microscopy (AFM) and optical tweezers have been used to characterize the forcedependent stretching behavior of the polymers listed above. An interpolation formula that describes the extension x of a WLC with contour length L_{0} and persistence length P in response to a stretching force F is
In the particular case of stretching DNA in physiological buffer (near neutral pH, ionic strength approximately 100 mM) at room temperature, the compliance of the DNA along the contour must be accounted for. This enthalpic compliance is accounted for by adding a stretch modulus K_{0} to the above relation:
See also
References


This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Wormlike_chain". A list of authors is available in Wikipedia. 