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Orthogonal and Complementary Nanoparticle Characterization Techniques

Combining Dynamic Light Scattering with Nanoparticle Tracking Analysis

Malvern Instruments Ltd.

3-step process involved in NTA measurements

Dynamic light scattering size distribution by intensity data for hemoglobin, showing the change in particle size associated with sample heating from 37°C to 44°C

Dynamic light scattering data for hemoglobin showing the change in particle size over time associated with sample heating at 41°C and 44°C

NanoSight NTA size distribution data for a mixture of 100 nm, 200 nm, 300 nm and 400 nm reference standards measured simultaneously, demonstrating the high resolution sizing capabilities of the technology

A schematic of the measurement position for DLS for (a) weakly scattering or low concentration samples and (b) concentrated or strongly scattering samples

Dynamic light scattering size data for 200 nm polystyrene reference standards measured at a range of sample dilutions using the Zetasizer Nano, showing a linear response in particle sizing irrespective of sample dilution

NanoSight instrument screen shots, showing fluorescently labeled liposomes suspended in fetal bovine serum, operating in light scatter mode (A) and fluorescence mode (B)

NanoSight particle by particle zeta potential distribution versus particle concentration data (A) and particle size versus particle zeta potential plot (B)

Schematic of the Malvern Instruments Zetasizer APS instrument

Malvern Instruments Zetasizer APS Plate Navigator software allows for powerful yet simple data analysis. Trends in data can be color coded to assist interpretation of results

The Zetasizer Nano dynamic light scattering instrument family and the NanoSight Nanoparticle Tracking Analysis instrument range complement each other perfectly, providing a suite of measurement capabilities useful to many researchers interested in characterizing nanoparticle and bioparticulate systems.

Both instruments measure particle size and zeta potential. The broad particle sizing range of the Zetasizer Nano is complemented by the high resolution single particle sizing of the NanoSight NTA. Routine, industry-standard zeta potential measurements as provided by the Zetasizer Nano are complemented by the high resolution zeta potential measurements of the NanoSight NTA which also allow for simultaneous measurement of particle size.

The Zetasizer APS instrument supplements these measurement parameters with the ability to measure particle size distribution in samples within 96 and 384 well plates, allowing for both routine and automated sample screening. The NIBS technology implemented in the Zetasizer Nano family allows for the measurement of samples across a broad range of sample concentrations, providing flexibility and the capacity to measure samples in an undiluted form.

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Facts, background information, dossiers
  • zeta potential analysis
  • particle size distribution
  • particle concentration
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