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GHK current equation
The eponyms of the equation
The American David E. Goldman of Columbia University, and the English Nobel laureates Alan Lloyd Hodgkin and Bernard Katz derived this equation.
Assumptions underlying the validity of the equation
Several assumptions are made in deriving the GHK current equation:
The GHK current equation for an ion S:
Rectification and the GHK current equation
Since one of the assumptions of the GHK current equation is that the ions move independently of each other, the total flow of ions across the membrane is simply equal to the sum of two oppositely directed fluxes. Each flux (or current) approaches an asymptotic value as the membrane potential diverges from zero. These asymptotes are
The GHK current equation is mostly used by electrophysiologists when the ratio between [S]i and [S]o is large and/or when one or both of the concentrations change considerably during an action potential. The most common example is probably intracellular calcium, [Ca2+]i, which during a cardiac action potential cycle can change 100-fold or more, and the ratio between [Ca2+]o and [Ca2+]i can reach 20,000 or more.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "GHK_current_equation". A list of authors is available in Wikipedia.|