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Nafcillin


Nafcillin
Systematic (IUPAC) name
7-[(2-ethoxynaphthalen-1-yl) carbonylamino]- 3,3-dimethyl-6-oxo-2-thia-5-azabicyclo [ 3.2.0] heptane-4-carboxylic acid
Identifiers
CAS number	985-16-0
ATC code	?
PubChem	8982
DrugBank	APRD01130
Chemical data
Formula	C₂₁H₂₂N₂O₅S
Mol. mass	414.476 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	90%
Metabolism	<30% hepatic
Half life	?
Excretion	Biliary and renal
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	IM, IV

Nafcillin sodium is a narrow spectrum beta-lactam antibiotic of the penicillin class. As a beta-lactamase-resistant penicillin, it is used to treat infections caused by Gram-positive bacteria, particularly species of Staphylococci, that are resistant to other penicillins.

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Side effects

As with all penicillins, serious life-threatening allergic reactions can occur.

Milder side effects include:

Nausea and vomiting
Diarrhea, often due to suppression of normal gastrointestinal bacteria. Occasionally, this leads to a more serious super-infection with an organism like Clostridium difficile
Abdominal pain
Yeast infections (thrush) affecting the mouth and tongue or vagina

v • d • e Antibacterials for systemic use: beta-lactam antibiotics - penicillins (J01C)
Antibiotics	Amoxicillin • Ampicillin • Azlocillin • Carbenicillin • Cloxacillin • Dicloxacillin • Flucloxacillin • Mezlocillin • Nafcillin • Piperacillin • Pivampicillin • Ticarcillin
Beta-lactamase inhibitors	Sulbactam • Tazobactam • Clavulanic acid
Combinations	Ampicillin/sulbactam (Sultamicillin) • Co-amoxiclav