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Look up Industrial Syntheses of 2,600 APIs

One-stop source of information relating to the industrial synthesis and commercial applications of every licensed drug of significance more

Synthesis Problems? Find Fast and Better Solutions for Organic Transformations

This tool for full-text reviews of organic transformations and experimental procedures helps improve your strategy for the design of new molecules more

Synthesis Problems? Find Fast and Better Solutions for Organic Transformations

Science of Synthesis is your one-stop tool for full-text reviews of organic transformations and experimental procedures. The online reference work helps speed up your literature research and improve your strategy for the design of new molecules. Science of Synthesis provides a critical revi ... more

Room-Temperature, Water-Promoted, Radical-Coupling Reactions of Phenols with tert-Butyl Nitrite

SynlettDOI: 10.1055/s-0036-1589038 A radical–radical cross-coupling reaction of phenols with tert-butyl nitrite has been developed with the use of water as an additive. This method allows the construction of C–N bonds under an air atmosphere at room temperature, providing the ortho-nitrate ... more

Direct ortho Arylation of Anisoles via the Formation of Four-Membered Lithiumcycles/Palladacycles

SynlettDOI: 10.1055/s-0036-1588863 We report here our latest discovery on the directed lithiation and palladium-catalyzed arylation of anisoles. During this research, the formation of a four-membered lithiumcycle followed by transmetalation to the corresponding palladacycle has been achiev ... more

Metal-free Oxidative Cross-Coupling Reaction of Aromatic Compounds Containing Heteroatoms

SynlettDOI: 10.1055/s-0036-1588455 The biaryl unit containing a heteroatom is a key structure in a large number of natural products and π-conjugated organic systems. The cross-couplings can provide powerful methods for the construction of biaryls and heterobiaryls; thus the development of ... more