Cross-Coupling

Many production facilities (e.g. plastic manufacturers, pharma companies, and others) use nanocatalysts that contain palladium--an expensive component that is not sustainably produced. A chemist from RUDN University found a way to reduce palladium consumption and to make its manufacture more eco-fri more

In Japan, puffer fish is considered a delicacy, but the tickle to the taste buds comes with a tickle to the nerves: fugu contains tetrodotoxin, a strong nerve toxin. In low doses, tetrodotoxin is shown in clinical trials to be a replacement for opioids for relieving cancer related pain. In the journ more

Adding olefin enables efficient solvent-free cross-coupling reactions, leading to environmentally friendly syntheses of a wide range of organic materials. A cross coupling reaction is typically performed in an organic solvent and leads to the production of a large amount of solvent waste, which is o more

A silica‐supported precatalyst, Pd‐PEPPSI‐IPent‐SiO2 (7), has been prepared and evaluated for its proficiency in the Negishi cross‐coupling of hindered and electronically deactivated coupling partners. Precatalyst 7 loaded into packed bed columns has shown very high catalytic activity for the room more

Journal of the American Chemical Society DOI: 10.1021/jacs.7b06630 more

Experimental and computational efforts are reported which illuminate the mechanism of a novel boron version of the widespread Negishi coupling reaction that offers a new protocol for the formation of aryl/acyl C‐B bonds using a bulky boryl fragment. The role of nucleophilic borylzinc reagents in t more