Lords of the molecular Rings: An Innovative Shortcut to High-Performance Organic Materials

A Game Changer for Advanced Technologies

19-Mar-2025 - Scientists at the Institute of Organic Chemistry, University of Vienna, have unveiled an innovative approach for synthesizing azaparacyclophanes (APCs), a class of highly advanced ring-shaped molecular structures with immense potential in material science. Their innovative Catalyst-Transfer ...

Anionic Nickel

Nickel-catalyzed cross-coupling of aromatic ethers proceeds via a nickelate anion

26-Oct-2021 - Metal catalysts are widely used in the production of drugs, dyes, adhesives, and plastics. Researchers have now discovered an intriguing property of nickel as a catalyst: it is able to catalyze the coupling of aromatic hydrocarbons in its anionic form, the nickelate ion. In this form, the two ...

Chemist developed a green catalyst for pharmaceutical and industrial chemistry

Catalyst based on a substance that comes from plant waste

08-Sep-2020 - Many production facilities (e.g. plastic manufacturers, pharma companies, and others) use nanocatalysts that contain palladium--an expensive component that is not sustainably produced. A chemist from RUDN University found a way to reduce palladium consumption and to make its manufacture more ...

Making Puffer Fish Toxin in a Flask

Total synthesis of tetrodotoxin

10-Mar-2020 - In Japan, puffer fish is considered a delicacy, but the tickle to the taste buds comes with a tickle to the nerves: fugu contains tetrodotoxin, a strong nerve toxin. In low doses, tetrodotoxin is shown in clinical trials to be a replacement for opioids for relieving cancer related pain. In the ...

Boosting solid state chemical reactions

13-Feb-2019 - Adding olefin enables efficient solvent-free cross-coupling reactions, leading to environmentally friendly syntheses of a wide range of organic materials. A cross coupling reaction is typically performed in an organic solvent and leads to the production of a large amount of solvent waste, which ...

Best of both worlds: Combining two skeleton-building chemical reactions

13-Aug-2018 - Scripps Research scientists have developed a powerful new strategy for synthesizing molecular skeletons of chemicals used in drugs and other important products, a technique that provides unprecedented flexibility and control over chemical synthesis. The method, which combines two chemical ...

New reaction turns feedstock chemical into versatile, chiral building block

30-Mar-2016 - Researchers in the Doyle lab at Princeton have developed a direct cross-coupling reaction to produce nitrogen-containing compounds called 1,2-dihydropyridines, versatile building blocks that are highly useful in pharmaceutical research. The reaction employs a chiral nickel catalyst and an ...

Transition metal catalyst prompts 'conjunctive' cross-coupling reaction

05-Jan-2016 - By employing a third reactant, researchers at Boston College have developed a new type of 'cross coupling' chemical reaction, building on a Nobel Prize-winning technique that is one of the most sophisticated tools available to research chemists. A key component of that novel approach - known as ...

Saltigo focuses on palladium-catalyzed cross-coupling reactions

Nobel Prize-winning chemistry in industrial use

28-Oct-2010 - Palladium-catalyzed cross-coupling reactions have become an important cornerstone of modern organic synthesis chemistry. They have made a wide variety of active pharmaceutical ingredients, natural substances and other complex organic molecules economically accessible. The award of this year's ...

The Nobel Prize in Chemistry 2010 given to three scientists

The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Chemistry for 2010 to Richard F. Heck, Ei-ichi Negishi and Akira Suzuki "for palladium-catalyzed cross couplings in organic synthesis"

06-Oct-2010 - Organic chemistry has developed into an art form where scientists produce marvelous chemical creations in their test tubes. Mankind benefits from this in the form of medicines, ever-more precise electronics and advanced technological materials. The Nobel Prize in Chemistry 2010 awards one of the ...