Cross-Coupling

Metal catalysts are widely used in the production of drugs, dyes, adhesives, and plastics. Researchers have now discovered an intriguing property of nickel as a catalyst: it is able to catalyze the coupling of aromatic hydrocarbons in its anionic form, the nickelate ion. In this form, the two metals more

Many production facilities (e.g. plastic manufacturers, pharma companies, and others) use nanocatalysts that contain palladium--an expensive component that is not sustainably produced. A chemist from RUDN University found a way to reduce palladium consumption and to make its manufacture more eco-fri more

In Japan, puffer fish is considered a delicacy, but the tickle to the taste buds comes with a tickle to the nerves: fugu contains tetrodotoxin, a strong nerve toxin. In low doses, tetrodotoxin is shown in clinical trials to be a replacement for opioids for relieving cancer related pain. In the journ more

A silica‐supported precatalyst, Pd‐PEPPSI‐IPent‐SiO2 (7), has been prepared and evaluated for its proficiency in the Negishi cross‐coupling of hindered and electronically deactivated coupling partners. Precatalyst 7 loaded into packed bed columns has shown very high catalytic activity for the room more

Journal of the American Chemical Society DOI: 10.1021/jacs.7b06630 more

Experimental and computational efforts are reported which illuminate the mechanism of a novel boron version of the widespread Negishi coupling reaction that offers a new protocol for the formation of aryl/acyl C‐B bonds using a bulky boryl fragment. The role of nucleophilic borylzinc reagents in t more