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2-Chloropropionic acid is the chemical compound with the formula CH3CHClCO2H. This colorless liquid is the simplest chiral chlorocarboxylic acid, and it is noteworthy for being readily available as a single enantiomer.
Additional recommended knowledge
Preparation and use in organic synthesis
Enantiomerically pure S-2-chloropropionic acid is prepared from alanine via diazotization in hydrochloric acid. Other α-amino acids undergo this reaction.
Reduction of S-2-chloropropionic acid with lithium aluminium hydride affords S-2-chloropropanol, the simplest chloro-alcohol. This alcohol undergoes cyclization upon treatment potassium hydroxide, which causes dehydrohalogenation to give the epoxide, R-methyloxirane.
In general, α-halocarboxylic acids and their esters are good alkylating agents and should be handled with care. 2-Chloropropionic acid is a neurotoxin.
Categories: Carboxylic acids | Organochlorides
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "2-Chloropropionic_acid". A list of authors is available in Wikipedia.|