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Systematic (IUPAC) name

propanediyl)]}bis[1-(3,4-dimethoxybenzyl) -6,7-dimethoxy-2-methyl-1,2,3,4- tetrahydroisoquinolinium]

CAS number 64228-79-1
ATC code M03AC04
PubChem 9751
DrugBank APRD00806
Chemical data
Formula C53H72N2O122+
Mol. mass 929.145 g/mol
Pharmacokinetic data
Bioavailability 100% (IV)
Protein binding 82%
Metabolism Hoffman elimination (retro-Michael addition) and ester hydrolysis
Half life 17-21 minutes
Excretion  ?
Therapeutic considerations
Pregnancy cat.


Legal status

POM (UK)and worldwide

Routes IV

Atracurium is a neuromuscular-blocking drug or skeletal muscle relaxant in the category of non-depolarising neuromuscular-blocking drugs, used adjunctively in anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.

Side effects owing to histamine liberation are rash, reflex increase in heart rate, low blood pressure and bronchospasm.

It is a bisbenzyltetrahydroisoquinolinium mixture of 10 stereoisomers. Atracurium was first synthesized, in 1974 by George H. Dewar, in John B. Stenlake's medicinal chemistry research group at Strathclyde University, Scotland. It is the first non-depolarising non-steroidal skeletal muscle relaxant rationally designed to undergo chemodegradation in vivo. Atracurium was licensed to Burroughs Wellcome Co., which developed atracurium and eventually marketed it (as a mixture of all ten stereoisomers) under the name Tracrium. Atracurium's rate of degradation in vivo is influenced by pH and temperature.

Atracurium was succeeded by cisatracurium, which is the R-cis R-cis isomer constituent of atracurium. The pharmacodynamic and adverse effect profile of cisatracurium proved to be superior to that of atracurium. Cisatracurium was made available worldwide as Nimbex, with its clinical development solely undertaken by Burroughs Wellcome Co.

Atracurium is classified as an intermediate-acting neuromuscular blocking agent.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Atracurium". A list of authors is available in Wikipedia.
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