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Systematic (IUPAC) name
2-(4-chlorophenyl)-3-methyl-1, 1-dioxo-1,3-thiazinan-4-one
CAS number 80-77-3
ATC code M03BB02
PubChem 2717
DrugBank APRD00865
Chemical data
Formula C11H12ClNO3S 
Mol. mass 273.737 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life 40.5 hr.
Excretion  ?
Therapeutic considerations
Pregnancy cat.


Legal status

-only(US) Withdrawn

Routes Oral

Chlormezanone (marketed under the brand name Trancopal) is a drug used as an anxiolytic and a muscle relaxant.

It was discontinued worldwide in 1996 by its manufacturer, due to rare but serious cases of toxic epidermal necrolysis.


  • Wollina U, Hipler U, Seeling A, Oelschlager H. "Investigations of interactions of chlormezanone racemate and its enantiomers on human keratinocytes and human leucoytes in vitro.". Skin Pharmacol Physiol 18 (3): 132-8. PMID 15897685.
  • Seeling A, Oelschläger H, Rothley D (2000). "Important pharmaceutical-chemical characteristics of the central muscle relaxant chlormezanone". Pharmazie 55 (4): 293-6. PMID 10798243.
  • Oelschläger H, Klinger W, Rothley D, Seeling A, Bockhard H, Hofmann B, Machts H, Riederer H, Rackur H (1998). "[Cleavage and biotransformation of the central muscle relaxant chlormezanone]". Pharmazie 53 (9): 620-4. PMID 9770210.
  • Gautier V, Vincon G, Demotes-Mainard F, Albin H (1990). "[Pharmacokinetics of chlormezanone in healthy volunteers] (original in French)". Pharmazie 45 (4): 315-9. PMID 2399514.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Chlormezanone". A list of authors is available in Wikipedia.
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