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Phenprobamate



Phenprobamate
Systematic (IUPAC) name
3-phenylpropylcarbamate
Identifiers
CAS number 673-31-4
ATC code M03BA01
PubChem 4770
Chemical data
Formula  ?
Mol. mass 179.22
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life 5 - 8 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

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Legal status
Routes  ?

Phenprobamate (Gamaquil, Isotonil) is a centrally acting skeletal muscle relaxant, with additional sedative and anticonvulsant effects. Overdose is similar to barbiturate. Its mechanism of action is probably similar to meprobamate. Phenprobamate was previously used in humans as an anxiolytic, and is still sometimes used in general anaesthesia and for treating muscle cramps and spasticity. Phenprobamate is still used in some european countries, but it has generally been replaced by newer drugs. Phenprobamate is metabolised by oxidative degradation of the amide group and ortho-hydroxylation of the benzene ring, and is eliminated in urine by the kidneys.

Additional recommended knowledge

Dose: 400 - 800 mg, up to 3 times a day




References

  • The Comparative Toxicogenomics Database: Phenprobamate
  • BIAM: Phenprobamate (French).
  • Chembank: Phenprobamate
  • Nephrology Dialysis Transplantation Volume 17, Number 5, Pp. 941. Letters: Haemoperfusion may be useful in phenprobamate and polypharmacy intoxication of paediatric patients.
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Phenprobamate". A list of authors is available in Wikipedia.
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