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Bisoctrizole



Bisoctrizole
IUPAC name 2,2'-methylenebis[6-(2H-benzotriazol-2-yl)

-4-(1,1,3,3-tetramethylbutyl)phenol]

Identifiers
CAS number 103597-45-l
Properties
Molecular formula C41H50N6O2
Molar mass 658.89 g/mol
Melting point

195.7 °C

Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references

Bisoctrizole (USAN[1], Tinosorb® M, INCI Methylene Bis-Benzotriazolyl Tetramethylbutylphenol) is a chemical which is added to sunscreens to absorb UV rays. It's marketed by Ciba Specialty Chemicals.

Additional recommended knowledge

Bisoctrizole is a broad spectrum ultraviolet radiation absorber, absorbing UVB as well as UVA rays. It also reflects and scatters UV. Bisoctrizole is a hybrid UV absorber. It's produced as small particles (< 200 nm)[2], like microfine zinc oxide and titanium dioxide. And it is organic like most sunscreen actives. It is added to the water phase of a sunscreen as a 50% suspension, while mineral micropigments are usually added to the oil phase.

Bisoctrizole shows very little photodegradation and has a stabilizing effect on other UV absorbers, octyl methoxycinnamate (octinoxate) in particular.

Unlike some other organic sunscreen actives, it shows no estrogenic effects in vitro.[3]

Bisoctrizole is not approved by the FDA, but is approved in the EU and other parts of the world.[4][5][6]

See also

Sunscreen

Avobenzone

References

  1. ^ http://www.ama-assn.org/ama1/pub/upload/mm/365/bisoctrizol.doc,
  2. ^ http://www.blackwell-synergy.com/doi/abs/10.1046/j.1467-2494.2002.00137.x
  3. ^ Ashby J, Tinwell H, Plautz J, Twomey K, Lefevre PA (Dec 2001). "Lack of binding to isolated estrogen or androgen receptors, and inactivity in the immature rat uterotrophic assay, of the ultraviolet sunscreen filters Tinosorb M-active and Tinosorb S". Regul Toxicol Pharmacol 34(3): 287-91. PMID 11754532.
  4. ^ http://www.modernmedicine.com/modernmedicine/article/articleDetail.jsp?id=169626
  5. ^ http://eur-lex.europa.eu/LexUriServ/site/en/consleg/1976/L/01976L0768-20060809-en.pdf
  6. ^ http://www.tga.gov.au/docs/pdf/argom_10.pdf


 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Bisoctrizole". A list of authors is available in Wikipedia.
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